Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination

An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged l...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuno, Masahiro, Sawa, Naoki, Mizuno, Hiroki, Oba, Yuki, Ikuma, Daisuke, Sekine, Akinari, Yamanouchi, Masayuki, Hasegawa, Eiko, Suwabe, Tatsuya, Saito, Satoshi, Kono, Kei, Kinowaki, Keiichi, Notohara, Kenji, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400404/
https://www.ncbi.nlm.nih.gov/pubmed/37005259
http://dx.doi.org/10.2169/internalmedicine.1634-23
Descripción
Sumario:An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged liver. Infiltration of IgG4-positive plasma cells, which accounted for approximately 74% of total plasma cells, was found in the portal area, but there was no evidence of periportal hepatitis, and inflammatory cell infiltration into the lobular space was minimal. IgG4-related hepatopathy was diagnosed. The patient achieved spontaneous remission with no treatment and only follow-up and remains under observation at the time of writing.

Ejemplares similares