Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination

An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged l...

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Autores principales: Kuno, Masahiro, Sawa, Naoki, Mizuno, Hiroki, Oba, Yuki, Ikuma, Daisuke, Sekine, Akinari, Yamanouchi, Masayuki, Hasegawa, Eiko, Suwabe, Tatsuya, Saito, Satoshi, Kono, Kei, Kinowaki, Keiichi, Notohara, Kenji, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400404/
https://www.ncbi.nlm.nih.gov/pubmed/37005259
http://dx.doi.org/10.2169/internalmedicine.1634-23
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author Kuno, Masahiro
Sawa, Naoki
Mizuno, Hiroki
Oba, Yuki
Ikuma, Daisuke
Sekine, Akinari
Yamanouchi, Masayuki
Hasegawa, Eiko
Suwabe, Tatsuya
Saito, Satoshi
Kono, Kei
Kinowaki, Keiichi
Notohara, Kenji
Ubara, Yoshifumi
author_facet Kuno, Masahiro
Sawa, Naoki
Mizuno, Hiroki
Oba, Yuki
Ikuma, Daisuke
Sekine, Akinari
Yamanouchi, Masayuki
Hasegawa, Eiko
Suwabe, Tatsuya
Saito, Satoshi
Kono, Kei
Kinowaki, Keiichi
Notohara, Kenji
Ubara, Yoshifumi
author_sort Kuno, Masahiro
collection PubMed
description An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged liver. Infiltration of IgG4-positive plasma cells, which accounted for approximately 74% of total plasma cells, was found in the portal area, but there was no evidence of periportal hepatitis, and inflammatory cell infiltration into the lobular space was minimal. IgG4-related hepatopathy was diagnosed. The patient achieved spontaneous remission with no treatment and only follow-up and remains under observation at the time of writing.
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spelling pubmed-104004042023-08-05 Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination Kuno, Masahiro Sawa, Naoki Mizuno, Hiroki Oba, Yuki Ikuma, Daisuke Sekine, Akinari Yamanouchi, Masayuki Hasegawa, Eiko Suwabe, Tatsuya Saito, Satoshi Kono, Kei Kinowaki, Keiichi Notohara, Kenji Ubara, Yoshifumi Intern Med Case Report An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged liver. Infiltration of IgG4-positive plasma cells, which accounted for approximately 74% of total plasma cells, was found in the portal area, but there was no evidence of periportal hepatitis, and inflammatory cell infiltration into the lobular space was minimal. IgG4-related hepatopathy was diagnosed. The patient achieved spontaneous remission with no treatment and only follow-up and remains under observation at the time of writing. The Japanese Society of Internal Medicine 2023-03-31 2023-07-15 /pmc/articles/PMC10400404/ /pubmed/37005259 http://dx.doi.org/10.2169/internalmedicine.1634-23 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kuno, Masahiro
Sawa, Naoki
Mizuno, Hiroki
Oba, Yuki
Ikuma, Daisuke
Sekine, Akinari
Yamanouchi, Masayuki
Hasegawa, Eiko
Suwabe, Tatsuya
Saito, Satoshi
Kono, Kei
Kinowaki, Keiichi
Notohara, Kenji
Ubara, Yoshifumi
Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title_full Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title_fullStr Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title_full_unstemmed Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title_short Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination
title_sort immunoglobulin g4-related hepatopathy after covid-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400404/
https://www.ncbi.nlm.nih.gov/pubmed/37005259
http://dx.doi.org/10.2169/internalmedicine.1634-23
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