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Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review
BACKGROUND: Dietary protein ingestion augments post (resistance) exercise muscle protein synthesis (MPS) rates. It is thought that the dose of leucine ingested within the protein (leucine threshold hypothesis) and the subsequent plasma leucine variables (leucine trigger hypothesis; peak magnitude, r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400406/ https://www.ncbi.nlm.nih.gov/pubmed/37537134 http://dx.doi.org/10.14814/phy2.15775 |
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author | Wilkinson, Kiera Koscien, Christopher P. Monteyne, Alistair J. Wall, Benjamin T. Stephens, Francis B. |
author_facet | Wilkinson, Kiera Koscien, Christopher P. Monteyne, Alistair J. Wall, Benjamin T. Stephens, Francis B. |
author_sort | Wilkinson, Kiera |
collection | PubMed |
description | BACKGROUND: Dietary protein ingestion augments post (resistance) exercise muscle protein synthesis (MPS) rates. It is thought that the dose of leucine ingested within the protein (leucine threshold hypothesis) and the subsequent plasma leucine variables (leucine trigger hypothesis; peak magnitude, rate of rise, and total availability) determine the magnitude of the postprandial postexercise MPS response. METHODS: A quantitative systematic review was performed extracting data from studies that recruited healthy adults, applied a bout of resistance exercise, ingested a bolus of protein within an hour of exercise, and measured plasma leucine concentrations and MPS rates (delta change from basal). RESULTS: Ingested leucine dose was associated with the magnitude of the MPS response in older, but not younger, adults over acute (0–2 h, r (2) = 0.64, p = 0.02) and the entire postprandial (>2 h, r (2) = 0.18, p = 0.01) period. However, no single plasma leucine variable possessed substantial predictive capacity over the magnitude of MPS rates in younger or older adults. CONCLUSION: Our data provide support that leucine dose provides predictive capacity over postprandial postexercise MPS responses in older adults. However, no threshold in older adults and no plasma leucine variable was correlated with the magnitude of the postexercise anabolic response. |
format | Online Article Text |
id | pubmed-10400406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104004062023-08-05 Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review Wilkinson, Kiera Koscien, Christopher P. Monteyne, Alistair J. Wall, Benjamin T. Stephens, Francis B. Physiol Rep Reviews BACKGROUND: Dietary protein ingestion augments post (resistance) exercise muscle protein synthesis (MPS) rates. It is thought that the dose of leucine ingested within the protein (leucine threshold hypothesis) and the subsequent plasma leucine variables (leucine trigger hypothesis; peak magnitude, rate of rise, and total availability) determine the magnitude of the postprandial postexercise MPS response. METHODS: A quantitative systematic review was performed extracting data from studies that recruited healthy adults, applied a bout of resistance exercise, ingested a bolus of protein within an hour of exercise, and measured plasma leucine concentrations and MPS rates (delta change from basal). RESULTS: Ingested leucine dose was associated with the magnitude of the MPS response in older, but not younger, adults over acute (0–2 h, r (2) = 0.64, p = 0.02) and the entire postprandial (>2 h, r (2) = 0.18, p = 0.01) period. However, no single plasma leucine variable possessed substantial predictive capacity over the magnitude of MPS rates in younger or older adults. CONCLUSION: Our data provide support that leucine dose provides predictive capacity over postprandial postexercise MPS responses in older adults. However, no threshold in older adults and no plasma leucine variable was correlated with the magnitude of the postexercise anabolic response. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10400406/ /pubmed/37537134 http://dx.doi.org/10.14814/phy2.15775 Text en © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Wilkinson, Kiera Koscien, Christopher P. Monteyne, Alistair J. Wall, Benjamin T. Stephens, Francis B. Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title_full | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title_fullStr | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title_full_unstemmed | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title_short | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review |
title_sort | association of postprandial postexercise muscle protein synthesis rates with dietary leucine: a systematic review |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400406/ https://www.ncbi.nlm.nih.gov/pubmed/37537134 http://dx.doi.org/10.14814/phy2.15775 |
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