Posttranslational splicing modifications as a key mechanism in cytarabine resistance in acute myeloid leukemia

Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, 85% of patients show resistance and only 10% overcome the disease. Using RNA-seq and phosphoproteomics, we show that RNA splicing and serine-arginine-rich (SR) proteins phosphorylation...

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Detalles Bibliográficos
Autores principales: Morales, María Luz, García-Vicente, Roberto, Rodríguez-García, Alba, Reyes-Palomares, Armando, Vincelle-Nieto, África, Álvarez, Noemí, Ortiz-Ruiz, Alejandra, Garrido-García, Vanesa, Giménez, Alicia, Carreño-Tarragona, Gonzalo, Sánchez, Ricardo, Ayala, Rosa, Martínez-López, Joaquín, Linares, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400425/
https://www.ncbi.nlm.nih.gov/pubmed/37422594
http://dx.doi.org/10.1038/s41375-023-01963-4

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