FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC. Fucosyltransferase 8 (FUT8) is a potential therapeutic target with high level in most malignant cancers including CRC. FUT...

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Detalles Bibliográficos
Autores principales: Wang, Mengmeng, Zhang, Zhoudong, Chen, Mengxi, Lv, Yixin, Tian, Sheng, Meng, Fanyi, Zhang, Yawen, Guo, Xuqin, Chen, Yinshuang, Yang, Man, Li, Jiawei, Qiu, Tian, Xu, Fang, Li, Zhi, Zhang, Qi, Yang, Jie, Sun, Jing, Zhang, Hongjian, Zhang, Haiyang, Li, Huanqiu, Wang, Weipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400579/
https://www.ncbi.nlm.nih.gov/pubmed/37537172
http://dx.doi.org/10.1038/s41419-023-06027-0

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