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Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms
A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functio...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400583/ https://www.ncbi.nlm.nih.gov/pubmed/37537178 http://dx.doi.org/10.1038/s41536-023-00318-y |
| _version_ | 1785084475255816192 |
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| author | Liu, Xiuxiu Han, Maoying Weng, Wendong Li, Yan Pu, Wenjuan Liu, Kuo Li, Xufeng He, Lingjuan Sun, Ruilin Shen, Ruling He, Yulong Liang, Dandan Chen, Yi-Han Wang, Qing-Dong Tchorz, Jan S. Zhou, Bin |
| author_facet | Liu, Xiuxiu Han, Maoying Weng, Wendong Li, Yan Pu, Wenjuan Liu, Kuo Li, Xufeng He, Lingjuan Sun, Ruilin Shen, Ruling He, Yulong Liang, Dandan Chen, Yi-Han Wang, Qing-Dong Tchorz, Jan S. Zhou, Bin |
| author_sort | Liu, Xiuxiu |
| collection | PubMed |
| description | A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver. |
| format | Online Article Text |
| id | pubmed-10400583 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104005832023-08-05 Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms Liu, Xiuxiu Han, Maoying Weng, Wendong Li, Yan Pu, Wenjuan Liu, Kuo Li, Xufeng He, Lingjuan Sun, Ruilin Shen, Ruling He, Yulong Liang, Dandan Chen, Yi-Han Wang, Qing-Dong Tchorz, Jan S. Zhou, Bin NPJ Regen Med Brief Communication A genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver. Nature Publishing Group UK 2023-08-03 /pmc/articles/PMC10400583/ /pubmed/37537178 http://dx.doi.org/10.1038/s41536-023-00318-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Liu, Xiuxiu Han, Maoying Weng, Wendong Li, Yan Pu, Wenjuan Liu, Kuo Li, Xufeng He, Lingjuan Sun, Ruilin Shen, Ruling He, Yulong Liang, Dandan Chen, Yi-Han Wang, Qing-Dong Tchorz, Jan S. Zhou, Bin Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title | Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title_full | Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title_fullStr | Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title_full_unstemmed | Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title_short | Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| title_sort | functional protracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400583/ https://www.ncbi.nlm.nih.gov/pubmed/37537178 http://dx.doi.org/10.1038/s41536-023-00318-y |
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