Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis

Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence accelerates prostatic oncogenesis. p53 gain-of-function (G...

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Detalles Bibliográficos
Autores principales: Ding, Donglin, Blee, Alexandra M., Zhang, Jianong, Pan, Yunqian, Becker, Nicole A., Maher, L. James, Jimenez, Rafael, Wang, Liguo, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400651/
https://www.ncbi.nlm.nih.gov/pubmed/37537199
http://dx.doi.org/10.1038/s41467-023-40352-4

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