Cargando…

A FinnGen pilot clinical recall study for Alzheimer’s disease

Successful development of novel therapies requires that clinical trials are conducted in patient cohorts with the highest benefit-to-risk ratio. Population-based biobanks with comprehensive health and genetic data from large numbers of individuals hold promise to facilitate identification of trial p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Julkunen, Valtteri, Schwarz, Claudia, Kalapudas, Juho, Hallikainen, Merja, Piironen, Aino-Kaisa, Mannermaa, Arto, Kujala, Hanna, Laitinen, Timo, Kosma, Veli-Matti, Paajanen, Teemu I., Kälviäinen, Reetta, Hiltunen, Mikko, Herukka, Sanna-Kaisa, Kärkkäinen, Sari, Kokkola, Tarja, Urjansson, Mia, Perola, Markus, Palotie, Aarno, Vuoksimaa, Eero, Runz, Heiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400697/ https://www.ncbi.nlm.nih.gov/pubmed/37537264 http://dx.doi.org/10.1038/s41598-023-39835-7

Ejemplares similares

FinnGen provides genetic insights from a well-phenotyped isolated population
por: Kurki, Mitja I., et al.
Publicado: (2023)

TWINGEN – protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer’s disease
por: Vuoksimaa, Eero, et al.
Publicado: (2023)

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population
por: Kurki, Mitja I., et al.
Publicado: (2023)

Recontacting biobank participants to collect lifestyle, behavioural and cognitive information via online questionnaires: lessons from a pilot study within FinnGen
por: Rodosthenous, Rodosthenis S, et al.
Publicado: (2022)

Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort
por: Ritari, Jarmo, et al.
Publicado: (2020)

Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer's Disease: Kuopio ALSOVA Study
por: Hallikainen, Ilona, et al.
Publicado: (2012)

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications
por: Changalidis, Anton I., et al.
Publicado: (2022)

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study
por: Si, Shucheng, et al.
Publicado: (2021)

Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen
por: Wu, E., et al.
Publicado: (2022)

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases
por: Jiang, Yi, et al.
Publicado: (2023)

Educational differences in self-rated physical fitness among Finns
por: Pulkkinen, Kaisa R, et al.
Publicado: (2013)

Cerebrospinal Fluid and MRI Biomarkers in Neurodegenerative Diseases: A Retrospective Memory Clinic-Based Study
por: Kaipainen, Aku, et al.
Publicado: (2020)

Cerebrospinal Fluid Diagnostics of Alzheimer’s Disease in Patients with Idiopathic Normal Pressure Hydrocephalus
por: Vanninen, Aleksi, et al.
Publicado: (2023)

Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus
por: Lukkarinen, Heikki, et al.
Publicado: (2023)

Overexpression of MicroRNA-200c Predicts Poor Outcome in Patients with PR-Negative Breast Cancer
por: Tuomarila, Marie, et al.
Publicado: (2014)

Structural MRI in Frontotemporal Dementia: Comparisons between Hippocampal Volumetry, Tensor-Based Morphometry and Voxel-Based Morphometry
por: Muñoz-Ruiz, Miguel Ángel, et al.
Publicado: (2012)

A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions
por: Kaipainen, Aku L, et al.
Publicado: (2021)

The Finns and their country
por: Hall, Wendy, 1913-1992
Publicado: (1967)

Aventuras de Huck Finn (The adventures of Huckleberry Finn) novela
por: Twain, Mark, 1835-1910
Publicado: (1943)

Phineas Finn : the Irish member
por: Trollope, Anthony, 1815-1882
Publicado: (1973)

Adventures of Huckleberry Finn /
por: Twain, Mark, 1835-1910
Publicado: (1999)

Finn's thermal physics
por: Rex, Andrew
Publicado: (2017)

Sleep-time physiological recovery is associated with eating habits in distressed working-age Finns with overweight: secondary analysis of a randomised controlled trial
por: Järvelä-Reijonen, Elina, et al.
Publicado: (2021)

Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study
por: Kärkkäinen, Henna, et al.
Publicado: (2014)

Type II Transmembrane Serine Protease Gene Variants Associate with Breast Cancer
por: Luostari, Kaisa, et al.
Publicado: (2014)

Impact of Mesh and Fixation on Chronic Inguinal Pain in Lichtenstein Hernia Repair: 5-Year Outcomes from the Finn Mesh Study
por: Matikainen, M., et al.
Publicado: (2020)

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus
por: Weiner, Sophia, et al.
Publicado: (2023)

The adventures of Hucleberry Finn : text and criticism /
por: Twain, Mark, 1835-1910
Publicado: (1984)

Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer’s Disease
por: Jääskeläinen, Olli, et al.
Publicado: (2020)

Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer
por: Berdel, Bozena, et al.
Publicado: (2012)

The debatable presence of PIWI‐interacting RNAs in invasive breast cancer
por: Kärkkäinen, Emmi, et al.
Publicado: (2021)

Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential
por: Kärkkäinen, Emmi, et al.
Publicado: (2022)

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival
por: Pelkonen, Mikko, et al.
Publicado: (2015)

Predicting AD Conversion: Comparison between Prodromal AD Guidelines and Computer Assisted PredictAD Tool
por: Liu, Yawu, et al.
Publicado: (2013)

Hostility in adolescents and adults: a genome-wide association study of the Young Finns
por: Merjonen, P, et al.
Publicado: (2011)

High Cell-Free DNA Integrity Is Associated with Poor Breast Cancer Survival
por: Lamminaho, Maria, et al.
Publicado: (2021)

The adventures of Huckleberry Finn : with exercises for study and vocabulary drill./
por: Twain, Mark, 1835-1910
Publicado: (1954)

Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women
por: Haapalinna, Fanni, et al.
Publicado: (2016)

Adventures of Huckleberry Finn : a case study in critical controversy
por: Twain, Mark, 1835-1910
Publicado: (1995)

γ-Secretase Components as Predictors of Breast Cancer Outcome
por: Peltonen, Hanna M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_hd1fo4rre6n15730pqpcf4luum