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Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids

STUDY OBJECTIVE: The purpose of this study is to rank the factors that are most and least important to patients with symptomatic uterine fibroids when considering surgical treatment options. MATERIALS AND METHODS: Using a best worst scaling (BWS) preference elicitation approach, participants complet...

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Autores principales: Babalola, Olufemi, Gebben, David, Tarver, Michelle E., Sangha, Roopina, Roberts, Jason, Price, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400705/
https://www.ncbi.nlm.nih.gov/pubmed/37210440
http://dx.doi.org/10.1007/s43441-023-00525-1
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author Babalola, Olufemi
Gebben, David
Tarver, Michelle E.
Sangha, Roopina
Roberts, Jason
Price, Veronica
author_facet Babalola, Olufemi
Gebben, David
Tarver, Michelle E.
Sangha, Roopina
Roberts, Jason
Price, Veronica
author_sort Babalola, Olufemi
collection PubMed
description STUDY OBJECTIVE: The purpose of this study is to rank the factors that are most and least important to patients with symptomatic uterine fibroids when considering surgical treatment options. MATERIALS AND METHODS: Using a best worst scaling (BWS) preference elicitation approach, participants completed an online survey to rank factors associated with fibroid surgical treatments. Survey content was based on a literature review and included the following factors: symptom relief; surgical complications; repeat treatment; recovery time; cosmetic effects; risk of spreading undiagnosed cancer; sexual outcomes; maintenance of child-bearing; continuation of menses; unpredictable menses; and location of procedure. Participants completed 11 BWS tasks. For each task, we presented participants with a subset of 5 factors from the possible 11, and participants chose the most important and least important factor. Participants’ responses were analyzed using conditional logistic regression to determine the relative importance of factors. Patient priorities were further explored via age and race. RESULTS: 285 respondents with symptomatic uterine fibroids (69 physician-confirmed and 216 self-reported) who had not undergone prior surgical treatment completed the survey. Respondents were enrolled from two clinical sites (clinical site cohort) and an online consumer panel (panel cohort). Both cohorts identified symptom relief, cancer risk, repeat treatment and complications as the most important factors in selecting surgical treatment options and location of procedure, return to normal activities after surgery, and cosmetic effects like presence of a scar after the surgical treatment as the least important factors. Of note, younger women (≤ 40) placed greater importance on the ability to have children after the procedure. CONCLUSION: Information regarding the factors most and least important to patients with symptomatic uterine fibroids might inform development and regulatory evaluation of new technologies and procedures. Study results may be useful in efforts to develop a set of outcomes to include in future fibroids clinical studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43441-023-00525-1.
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spelling pubmed-104007052023-08-05 Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids Babalola, Olufemi Gebben, David Tarver, Michelle E. Sangha, Roopina Roberts, Jason Price, Veronica Ther Innov Regul Sci Original Research STUDY OBJECTIVE: The purpose of this study is to rank the factors that are most and least important to patients with symptomatic uterine fibroids when considering surgical treatment options. MATERIALS AND METHODS: Using a best worst scaling (BWS) preference elicitation approach, participants completed an online survey to rank factors associated with fibroid surgical treatments. Survey content was based on a literature review and included the following factors: symptom relief; surgical complications; repeat treatment; recovery time; cosmetic effects; risk of spreading undiagnosed cancer; sexual outcomes; maintenance of child-bearing; continuation of menses; unpredictable menses; and location of procedure. Participants completed 11 BWS tasks. For each task, we presented participants with a subset of 5 factors from the possible 11, and participants chose the most important and least important factor. Participants’ responses were analyzed using conditional logistic regression to determine the relative importance of factors. Patient priorities were further explored via age and race. RESULTS: 285 respondents with symptomatic uterine fibroids (69 physician-confirmed and 216 self-reported) who had not undergone prior surgical treatment completed the survey. Respondents were enrolled from two clinical sites (clinical site cohort) and an online consumer panel (panel cohort). Both cohorts identified symptom relief, cancer risk, repeat treatment and complications as the most important factors in selecting surgical treatment options and location of procedure, return to normal activities after surgery, and cosmetic effects like presence of a scar after the surgical treatment as the least important factors. Of note, younger women (≤ 40) placed greater importance on the ability to have children after the procedure. CONCLUSION: Information regarding the factors most and least important to patients with symptomatic uterine fibroids might inform development and regulatory evaluation of new technologies and procedures. Study results may be useful in efforts to develop a set of outcomes to include in future fibroids clinical studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43441-023-00525-1. Springer International Publishing 2023-05-20 2023 /pmc/articles/PMC10400705/ /pubmed/37210440 http://dx.doi.org/10.1007/s43441-023-00525-1 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Babalola, Olufemi
Gebben, David
Tarver, Michelle E.
Sangha, Roopina
Roberts, Jason
Price, Veronica
Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title_full Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title_fullStr Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title_full_unstemmed Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title_short Patient Preferences Regarding Surgical Treatment Methods for Symptomatic Uterine Fibroids
title_sort patient preferences regarding surgical treatment methods for symptomatic uterine fibroids
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400705/
https://www.ncbi.nlm.nih.gov/pubmed/37210440
http://dx.doi.org/10.1007/s43441-023-00525-1
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