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A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate...

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Autores principales: Anaeigoudari, Fatemeh, Anaeigoudari, Akbar, Kheirkhah‐Vakilabad, Aliasghar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400758/
https://www.ncbi.nlm.nih.gov/pubmed/37537722
http://dx.doi.org/10.14814/phy2.15785
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author Anaeigoudari, Fatemeh
Anaeigoudari, Akbar
Kheirkhah‐Vakilabad, Aliasghar
author_facet Anaeigoudari, Fatemeh
Anaeigoudari, Akbar
Kheirkhah‐Vakilabad, Aliasghar
author_sort Anaeigoudari, Fatemeh
collection PubMed
description Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate that therapeutic impacts of saffron and its constituents, crocin, crocetin, and safranal, mainly are mediated via inhibiting the inflammatory reactions and scavenging free radicals. It has been suggested that saffron and crocin extracted from it also up‐regulate the expression of sirtuin 1 (SIRT1) and nuclear factor erythroid 2‐related factor 2 (Nrf2), down‐regulate nuclear factor kappa B (NF‐κB) signaling pathway and untimely improve the body organs dysfunction. Inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 (COX2) also is attributed to crocin. The current review narrates the therapeutic effects of saffron and its constituents on various body systems through looking for the scientific databases including Web of Science, PubMed, Scopus, and Google Scholar from the beginning of 2010 until the end of 2022.
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spelling pubmed-104007582023-08-05 A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents Anaeigoudari, Fatemeh Anaeigoudari, Akbar Kheirkhah‐Vakilabad, Aliasghar Physiol Rep Reviews Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate that therapeutic impacts of saffron and its constituents, crocin, crocetin, and safranal, mainly are mediated via inhibiting the inflammatory reactions and scavenging free radicals. It has been suggested that saffron and crocin extracted from it also up‐regulate the expression of sirtuin 1 (SIRT1) and nuclear factor erythroid 2‐related factor 2 (Nrf2), down‐regulate nuclear factor kappa B (NF‐κB) signaling pathway and untimely improve the body organs dysfunction. Inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 (COX2) also is attributed to crocin. The current review narrates the therapeutic effects of saffron and its constituents on various body systems through looking for the scientific databases including Web of Science, PubMed, Scopus, and Google Scholar from the beginning of 2010 until the end of 2022. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10400758/ /pubmed/37537722 http://dx.doi.org/10.14814/phy2.15785 Text en © 2023 Jiroft University of Medical Sciences. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Anaeigoudari, Fatemeh
Anaeigoudari, Akbar
Kheirkhah‐Vakilabad, Aliasghar
A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title_full A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title_fullStr A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title_full_unstemmed A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title_short A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
title_sort review of therapeutic impacts of saffron (crocus sativus l.) and its constituents
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400758/
https://www.ncbi.nlm.nih.gov/pubmed/37537722
http://dx.doi.org/10.14814/phy2.15785
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