RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function

Endoplasmic reticulum (ER) stress has been linked with various acute and chronic neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases induce neuronal ER stress in retinal ganglion cells (RGCs). We further demonstrated that germline deletion of CHOP preserves the...

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Detalles Bibliográficos
Autores principales: Fang, Fang, Liu, Pingting, Huang, Haoliang, Feng, Xue, Li, Liang, Sun, Yang, Kaufman, Randal J., Hu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400881/
https://www.ncbi.nlm.nih.gov/pubmed/37547290
http://dx.doi.org/10.1016/j.omtn.2023.07.015

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