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Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort

Psychotropic drugs are often used to treat behavior problems in ASD with some evidence supporting efficacity (e.g.: risperidone and irritability) but also significant side effects at the short and longer-term. It is then essential to know better the factors associated with the prescription of these...

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Autores principales: Geoffray, Marie-maude, Baltazar, Matias, Michelon, Cécile, Jurek, Lucie, Baghdadli, Amaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400887/
https://www.ncbi.nlm.nih.gov/pubmed/37547200
http://dx.doi.org/10.3389/fpsyt.2023.1153543
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author Geoffray, Marie-maude
Baltazar, Matias
Michelon, Cécile
Jurek, Lucie
Baghdadli, Amaria
author_facet Geoffray, Marie-maude
Baltazar, Matias
Michelon, Cécile
Jurek, Lucie
Baghdadli, Amaria
author_sort Geoffray, Marie-maude
collection PubMed
description Psychotropic drugs are often used to treat behavior problems in ASD with some evidence supporting efficacity (e.g.: risperidone and irritability) but also significant side effects at the short and longer-term. It is then essential to know better the factors associated with the prescription of these medications and potentially implement early behavioral and psychosocial intervention or cognitive remediation before to use medication. We designed a case–control study based on the population of the ELENA cohort to assess the factors associated with early psychotropic drugs use in children with ASD. Externalized behavior symptoms (measured by the Child Behavior Checklist) is the leading risk factor during the first years of follow-up (aOR = 2.8; CI [1.04; 7.67]; p = 0.04). Age, gender, autism severity, adaptive behaviors, or internalized behaviors were not associated with psychotropic medication prescription. Low IQ and parents who had received training tended to increase the risk of psychotropic medication prescription during follow-up but were not statistically significant. These findings underscore the need for early identification of symptoms of externalizing behaviour, early appropriate information for parents about treatment with and without medication, early analysis of externalising behaviour and targeted treatments.
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spelling pubmed-104008872023-08-05 Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort Geoffray, Marie-maude Baltazar, Matias Michelon, Cécile Jurek, Lucie Baghdadli, Amaria Front Psychiatry Psychiatry Psychotropic drugs are often used to treat behavior problems in ASD with some evidence supporting efficacity (e.g.: risperidone and irritability) but also significant side effects at the short and longer-term. It is then essential to know better the factors associated with the prescription of these medications and potentially implement early behavioral and psychosocial intervention or cognitive remediation before to use medication. We designed a case–control study based on the population of the ELENA cohort to assess the factors associated with early psychotropic drugs use in children with ASD. Externalized behavior symptoms (measured by the Child Behavior Checklist) is the leading risk factor during the first years of follow-up (aOR = 2.8; CI [1.04; 7.67]; p = 0.04). Age, gender, autism severity, adaptive behaviors, or internalized behaviors were not associated with psychotropic medication prescription. Low IQ and parents who had received training tended to increase the risk of psychotropic medication prescription during follow-up but were not statistically significant. These findings underscore the need for early identification of symptoms of externalizing behaviour, early appropriate information for parents about treatment with and without medication, early analysis of externalising behaviour and targeted treatments. Frontiers Media S.A. 2023-07-21 /pmc/articles/PMC10400887/ /pubmed/37547200 http://dx.doi.org/10.3389/fpsyt.2023.1153543 Text en Copyright © 2023 Geoffray, Baltazar, Michelon, Jurek and Baghdadli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Geoffray, Marie-maude
Baltazar, Matias
Michelon, Cécile
Jurek, Lucie
Baghdadli, Amaria
Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title_full Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title_fullStr Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title_full_unstemmed Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title_short Clinical predictors of psychotropic medication prescription in children with ASD of the ELENA cohort
title_sort clinical predictors of psychotropic medication prescription in children with asd of the elena cohort
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400887/
https://www.ncbi.nlm.nih.gov/pubmed/37547200
http://dx.doi.org/10.3389/fpsyt.2023.1153543
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