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Imaging of post-synaptic membrane trafficking in neuronal dendrites: progress, limitations, and new developments

Membrane trafficking of post-synaptic cargo is a key determinant of synaptic transmission and synaptic plasticity. We describe here the latest developments in visualizing individual exocytosis and endocytosis events in neurons using pH-sensitive tags. We show how these tools help decipher the spatia...

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Detalles Bibliográficos
Autores principales: Perrais, David, Sposini, Silvia, Angibaud, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400899/
https://www.ncbi.nlm.nih.gov/pubmed/37547562
http://dx.doi.org/10.1117/1.NPh.10.4.044404
Descripción
Sumario:Membrane trafficking of post-synaptic cargo is a key determinant of synaptic transmission and synaptic plasticity. We describe here the latest developments in visualizing individual exocytosis and endocytosis events in neurons using pH-sensitive tags. We show how these tools help decipher the spatial and temporal regulation of membrane trafficking steps during synaptic plasticity.