Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Dampening functional levels of the mitochondrial deubiquitylating enzyme Ubiquitin-specific protease 30 (USP30) has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired...

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Detalles Bibliográficos
Autores principales: O'Brien, Darragh P., Jones, Hannah B.L., Guenther, Franziska, Murphy, Emma J., England, Katherine S., Vendrell, Iolanda, Anderson, Malcolm, Brennan, Paul E., Davis, John B., Pinto-Fernández, Adán, Turnbull, Andrew P., Kessler, Benedikt M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400906/
https://www.ncbi.nlm.nih.gov/pubmed/37385347
http://dx.doi.org/10.1016/j.mcpro.2023.100609

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