Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma

Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. Here, we utilize RNA sequencing and metabolomics to identify candidate molecular effectors activated by these genetic drivers. We find glut...

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Detalles Bibliográficos
Autores principales: Gopal, Raj K., Vantaku, Venkata R., Panda, Apekshya, Reimer, Bryn, Rath, Sneha, To, Tsz-Leung, Fisch, Adam S., Cetinbas, Murat, Livneh, Maia, Calcaterra, Michael J., Gigliotti, Benjamin J., Pierce, Kerry A., Clish, Clary B., Dias-Santagata, Dora, Sadow, Peter M., Wirth, Lori J., Daniels, Gilbert H., Sadreyev, Ruslan I., Calvo, Sarah E., Parangi, Sareh, Mootha, Vamsi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401073/
https://www.ncbi.nlm.nih.gov/pubmed/37262067
http://dx.doi.org/10.1158/2159-8290.CD-22-0976

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