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Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis
BACKGROUND: Posttraumatic epilepsy (PTE) is one of the most critical complications of traumatic brain injury (TBI), significantly increasing TBI patients' neuropsychiatric symptoms and mortality. The abnormal accumulation of glutamate caused by TBI and its secondary excitotoxicity are essential...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401093/ https://www.ncbi.nlm.nih.gov/pubmed/37309302 http://dx.doi.org/10.1111/cns.14294 |
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author | Gao, Yuan Liu, Ning Chen, Juan Zheng, Ping Niu, Jianguo Tang, Shengsong Peng, Xiaodong Wu, Jing Yu, Jianqiang Ma, Lin |
author_facet | Gao, Yuan Liu, Ning Chen, Juan Zheng, Ping Niu, Jianguo Tang, Shengsong Peng, Xiaodong Wu, Jing Yu, Jianqiang Ma, Lin |
author_sort | Gao, Yuan |
collection | PubMed |
description | BACKGROUND: Posttraumatic epilepsy (PTE) is one of the most critical complications of traumatic brain injury (TBI), significantly increasing TBI patients' neuropsychiatric symptoms and mortality. The abnormal accumulation of glutamate caused by TBI and its secondary excitotoxicity are essential reasons for neural network reorganization and functional neural plasticity changes, contributing to the occurrence and development of PTE. Restoring glutamate balance in the early stage of TBI is expected to play a neuroprotective role and reduce the risk of PTE. AIMS: To provide a neuropharmacological insight for drug development to prevent PTE based on regulating glutamate homeostasis. METHODS: We discussed how TBI affects glutamate homeostasis and its relationship with PTE. Furthermore, we also summarized the research progress of molecular pathways for regulating glutamate homeostasis after TBI and pharmacological studies aim to prevent PTE by restoring glutamate balance. RESULTS: TBI can lead to the accumulation of glutamate in the brain, which increases the risk of PTE. Targeting the molecular pathways affecting glutamate homeostasis helps restore normal glutamate levels and is neuroprotective. DISCUSSION: Taking glutamate homeostasis regulation as a means for new drug development can avoid the side effects caused by direct inhibition of glutamate receptors, expecting to alleviate the diseases related to abnormal glutamate levels in the brain, such as PTE, Parkinson's disease, depression, and cognitive impairment. CONCLUSION: It is a promising strategy to regulate glutamate homeostasis through pharmacological methods after TBI, thereby decreasing nerve injury and preventing PTE. |
format | Online Article Text |
id | pubmed-10401093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104010932023-08-05 Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis Gao, Yuan Liu, Ning Chen, Juan Zheng, Ping Niu, Jianguo Tang, Shengsong Peng, Xiaodong Wu, Jing Yu, Jianqiang Ma, Lin CNS Neurosci Ther Reviews BACKGROUND: Posttraumatic epilepsy (PTE) is one of the most critical complications of traumatic brain injury (TBI), significantly increasing TBI patients' neuropsychiatric symptoms and mortality. The abnormal accumulation of glutamate caused by TBI and its secondary excitotoxicity are essential reasons for neural network reorganization and functional neural plasticity changes, contributing to the occurrence and development of PTE. Restoring glutamate balance in the early stage of TBI is expected to play a neuroprotective role and reduce the risk of PTE. AIMS: To provide a neuropharmacological insight for drug development to prevent PTE based on regulating glutamate homeostasis. METHODS: We discussed how TBI affects glutamate homeostasis and its relationship with PTE. Furthermore, we also summarized the research progress of molecular pathways for regulating glutamate homeostasis after TBI and pharmacological studies aim to prevent PTE by restoring glutamate balance. RESULTS: TBI can lead to the accumulation of glutamate in the brain, which increases the risk of PTE. Targeting the molecular pathways affecting glutamate homeostasis helps restore normal glutamate levels and is neuroprotective. DISCUSSION: Taking glutamate homeostasis regulation as a means for new drug development can avoid the side effects caused by direct inhibition of glutamate receptors, expecting to alleviate the diseases related to abnormal glutamate levels in the brain, such as PTE, Parkinson's disease, depression, and cognitive impairment. CONCLUSION: It is a promising strategy to regulate glutamate homeostasis through pharmacological methods after TBI, thereby decreasing nerve injury and preventing PTE. John Wiley and Sons Inc. 2023-06-12 /pmc/articles/PMC10401093/ /pubmed/37309302 http://dx.doi.org/10.1111/cns.14294 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Gao, Yuan Liu, Ning Chen, Juan Zheng, Ping Niu, Jianguo Tang, Shengsong Peng, Xiaodong Wu, Jing Yu, Jianqiang Ma, Lin Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title | Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title_full | Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title_fullStr | Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title_full_unstemmed | Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title_short | Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
title_sort | neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401093/ https://www.ncbi.nlm.nih.gov/pubmed/37309302 http://dx.doi.org/10.1111/cns.14294 |
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