Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report

The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinar...

Descripción completa

Detalles Bibliográficos
Autores principales: Peretto, Giovanni, De Luca, Giacomo, Villatore, Andrea, Di Resta, Chiara, Sala, Simone, Palmisano, Anna, Vignale, Davide, Campochiaro, Corrado, Lazzeroni, Davide, De Gaspari, Monica, Rizzo, Stefania, Busnardo, Elena, Ferro, Paola, Gianolli, Luigi, Basso, Cristina, Dagna, Lorenzo, Esposito, Antonio, Benedetti, Sara, Della Bella, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401291/
https://www.ncbi.nlm.nih.gov/pubmed/37547072
http://dx.doi.org/10.1016/j.jacbts.2023.02.018
Descripción
Sumario:The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients.

Ejemplares similares