Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report

The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinar...

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Autores principales: Peretto, Giovanni, De Luca, Giacomo, Villatore, Andrea, Di Resta, Chiara, Sala, Simone, Palmisano, Anna, Vignale, Davide, Campochiaro, Corrado, Lazzeroni, Davide, De Gaspari, Monica, Rizzo, Stefania, Busnardo, Elena, Ferro, Paola, Gianolli, Luigi, Basso, Cristina, Dagna, Lorenzo, Esposito, Antonio, Benedetti, Sara, Della Bella, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401291/
https://www.ncbi.nlm.nih.gov/pubmed/37547072
http://dx.doi.org/10.1016/j.jacbts.2023.02.018
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author Peretto, Giovanni
De Luca, Giacomo
Villatore, Andrea
Di Resta, Chiara
Sala, Simone
Palmisano, Anna
Vignale, Davide
Campochiaro, Corrado
Lazzeroni, Davide
De Gaspari, Monica
Rizzo, Stefania
Busnardo, Elena
Ferro, Paola
Gianolli, Luigi
Basso, Cristina
Dagna, Lorenzo
Esposito, Antonio
Benedetti, Sara
Della Bella, Paolo
author_facet Peretto, Giovanni
De Luca, Giacomo
Villatore, Andrea
Di Resta, Chiara
Sala, Simone
Palmisano, Anna
Vignale, Davide
Campochiaro, Corrado
Lazzeroni, Davide
De Gaspari, Monica
Rizzo, Stefania
Busnardo, Elena
Ferro, Paola
Gianolli, Luigi
Basso, Cristina
Dagna, Lorenzo
Esposito, Antonio
Benedetti, Sara
Della Bella, Paolo
author_sort Peretto, Giovanni
collection PubMed
description The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients.
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spelling pubmed-104012912023-08-05 Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report Peretto, Giovanni De Luca, Giacomo Villatore, Andrea Di Resta, Chiara Sala, Simone Palmisano, Anna Vignale, Davide Campochiaro, Corrado Lazzeroni, Davide De Gaspari, Monica Rizzo, Stefania Busnardo, Elena Ferro, Paola Gianolli, Luigi Basso, Cristina Dagna, Lorenzo Esposito, Antonio Benedetti, Sara Della Bella, Paolo JACC Basic Transl Sci Original Research - Clinical The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients. Elsevier 2023-07-05 /pmc/articles/PMC10401291/ /pubmed/37547072 http://dx.doi.org/10.1016/j.jacbts.2023.02.018 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Clinical
Peretto, Giovanni
De Luca, Giacomo
Villatore, Andrea
Di Resta, Chiara
Sala, Simone
Palmisano, Anna
Vignale, Davide
Campochiaro, Corrado
Lazzeroni, Davide
De Gaspari, Monica
Rizzo, Stefania
Busnardo, Elena
Ferro, Paola
Gianolli, Luigi
Basso, Cristina
Dagna, Lorenzo
Esposito, Antonio
Benedetti, Sara
Della Bella, Paolo
Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title_full Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title_fullStr Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title_full_unstemmed Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title_short Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report
title_sort multimodal detection and targeting of biopsy-proven myocardial inflammation in genetic cardiomyopathies: a pilot report
topic Original Research - Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401291/
https://www.ncbi.nlm.nih.gov/pubmed/37547072
http://dx.doi.org/10.1016/j.jacbts.2023.02.018
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