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Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart
B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised c...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401293/ https://www.ncbi.nlm.nih.gov/pubmed/37547075 http://dx.doi.org/10.1016/j.jacbts.2022.12.013 |
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author | Wang, JuFang Tomar, Dhadendra Martin, Thomas G. Dubey, Shubham Dubey, Praveen K. Song, Jianliang Landesberg, Gavin McCormick, Michael G. Myers, Valerie D. Merali, Salim Merali, Carmen Lemster, Bonnie McTiernan, Charles F. Khalili, Kamel Madesh, Muniswamy Cheung, Joseph Y. Kirk, Jonathan A. Feldman, Arthur M. |
author_facet | Wang, JuFang Tomar, Dhadendra Martin, Thomas G. Dubey, Shubham Dubey, Praveen K. Song, Jianliang Landesberg, Gavin McCormick, Michael G. Myers, Valerie D. Merali, Salim Merali, Carmen Lemster, Bonnie McTiernan, Charles F. Khalili, Kamel Madesh, Muniswamy Cheung, Joseph Y. Kirk, Jonathan A. Feldman, Arthur M. |
author_sort | Wang, JuFang |
collection | PubMed |
description | B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome. |
format | Online Article Text |
id | pubmed-10401293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104012932023-08-05 Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart Wang, JuFang Tomar, Dhadendra Martin, Thomas G. Dubey, Shubham Dubey, Praveen K. Song, Jianliang Landesberg, Gavin McCormick, Michael G. Myers, Valerie D. Merali, Salim Merali, Carmen Lemster, Bonnie McTiernan, Charles F. Khalili, Kamel Madesh, Muniswamy Cheung, Joseph Y. Kirk, Jonathan A. Feldman, Arthur M. JACC Basic Transl Sci Original Research - Preclinical B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome. Elsevier 2023-04-19 /pmc/articles/PMC10401293/ /pubmed/37547075 http://dx.doi.org/10.1016/j.jacbts.2022.12.013 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research - Preclinical Wang, JuFang Tomar, Dhadendra Martin, Thomas G. Dubey, Shubham Dubey, Praveen K. Song, Jianliang Landesberg, Gavin McCormick, Michael G. Myers, Valerie D. Merali, Salim Merali, Carmen Lemster, Bonnie McTiernan, Charles F. Khalili, Kamel Madesh, Muniswamy Cheung, Joseph Y. Kirk, Jonathan A. Feldman, Arthur M. Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title | Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title_full | Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title_fullStr | Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title_full_unstemmed | Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title_short | Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart |
title_sort | bag3 regulates mitochondrial function and the inflammasome through canonical and noncanonical pathways in the heart |
topic | Original Research - Preclinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401293/ https://www.ncbi.nlm.nih.gov/pubmed/37547075 http://dx.doi.org/10.1016/j.jacbts.2022.12.013 |
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