Bioprosthetic Valve Deterioration: Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium

Histologic evaluations revealed excessive accumulations of macrophages and absence of fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene and protein expression analysis and histology unveiled an accumulation of fibrinogen and plasminogen, an activator of infiltrate...

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Detalles Bibliográficos
Autores principales: Sakaue, Tomohisa, Koyama, Tadaaki, Nakamura, Yoshitsugu, Okamoto, Keitaro, Kawashima, Takayuki, Umeno, Tadashi, Nakayama, Yasuhide, Miyamoto, Shinji, Shikata, Fumiaki, Hamaguchi, Mika, Aono, Jun, Kurata, Mie, Namiguchi, Kenji, Uchita, Shunji, Masumoto, Junya, Yamaguchi, Osamu, Higashiyama, Shigeki, Izutani, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401294/
https://www.ncbi.nlm.nih.gov/pubmed/37547071
http://dx.doi.org/10.1016/j.jacbts.2023.01.003

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