Cargando…

Evaluation of the nutritional status of patients with liver cirrhosis

BACKGROUND: Progressive malnutrition coexists with liver diseases, particularly in patients with cirrhosis. Early diagnosis of malnutrition in patients with advanced stages of chronic liver disease and the implementation of appropriate nutritional treatment for malnourished patients should be an int...

Descripción completa

Detalles Bibliográficos
Autores principales: Janota, Barbara, Krupowicz, Aneta, Noras, Kinga, Janczewska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401412/
https://www.ncbi.nlm.nih.gov/pubmed/37547031
http://dx.doi.org/10.4254/wjh.v15.i7.914
_version_ 1785084656794730496
author Janota, Barbara
Krupowicz, Aneta
Noras, Kinga
Janczewska, Ewa
author_facet Janota, Barbara
Krupowicz, Aneta
Noras, Kinga
Janczewska, Ewa
author_sort Janota, Barbara
collection PubMed
description BACKGROUND: Progressive malnutrition coexists with liver diseases, particularly in patients with cirrhosis. Early diagnosis of malnutrition in patients with advanced stages of chronic liver disease and the implementation of appropriate nutritional treatment for malnourished patients should be an integral part of the therapeutic process. AIM: To evaluate the nutritional status of patients with various severities of advanced liver fibrosis, using various nutritional status parameters. METHODS: This study involved 118 patients with liver cirrhosis who were classified into three groups according to their Child-Pugh score. The nutritional status of the patients in each group was assessed using different methods. The average values obtained from the measurements were calculated for each research group. The influence of disease stage on the examined parameters of nutritional status was determined using one-way analysis of variance. To investigate the relationship between the parameters determining nutritional status and the stage of disease advancement, a correlation analysis was performed. RESULTS: The Child-Pugh A group had the highest mean body weight (76.42 kg), highest mean body mass index (BMI) (26.72 kg/m²), and largest mean arm circumference (27.64 cm). In the Child-Pugh B group, the mean scores of all examined variables were lower than those of the Child-Pugh A group, whereas the mean body weight and BMI of the Child-Pugh C group were higher than those of the Child-Pugh B group. There was a very strong correlation between the Child-Pugh classification and subjective global assessment score; a very strong correlation between the Child-Pugh classification and arm circumference; a strong correlation between the Child-Pugh classification and body weight, albumin concentration, fat-free mass index, muscle mass index, phase angle, and BMI; and an average correlation between Child-Pugh classification and fat mass index. Notably, these indicators deteriorated with disease progression. CONCLUSION: Advanced liver fibrosis leads to the deterioration of many nutritional status parameters. The extent of malnutrition increases with the progression of liver fibrosis. The Child-Pugh score reflects the nutritional status.
format Online
Article
Text
id pubmed-10401412
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-104014122023-08-05 Evaluation of the nutritional status of patients with liver cirrhosis Janota, Barbara Krupowicz, Aneta Noras, Kinga Janczewska, Ewa World J Hepatol Observational Study BACKGROUND: Progressive malnutrition coexists with liver diseases, particularly in patients with cirrhosis. Early diagnosis of malnutrition in patients with advanced stages of chronic liver disease and the implementation of appropriate nutritional treatment for malnourished patients should be an integral part of the therapeutic process. AIM: To evaluate the nutritional status of patients with various severities of advanced liver fibrosis, using various nutritional status parameters. METHODS: This study involved 118 patients with liver cirrhosis who were classified into three groups according to their Child-Pugh score. The nutritional status of the patients in each group was assessed using different methods. The average values obtained from the measurements were calculated for each research group. The influence of disease stage on the examined parameters of nutritional status was determined using one-way analysis of variance. To investigate the relationship between the parameters determining nutritional status and the stage of disease advancement, a correlation analysis was performed. RESULTS: The Child-Pugh A group had the highest mean body weight (76.42 kg), highest mean body mass index (BMI) (26.72 kg/m²), and largest mean arm circumference (27.64 cm). In the Child-Pugh B group, the mean scores of all examined variables were lower than those of the Child-Pugh A group, whereas the mean body weight and BMI of the Child-Pugh C group were higher than those of the Child-Pugh B group. There was a very strong correlation between the Child-Pugh classification and subjective global assessment score; a very strong correlation between the Child-Pugh classification and arm circumference; a strong correlation between the Child-Pugh classification and body weight, albumin concentration, fat-free mass index, muscle mass index, phase angle, and BMI; and an average correlation between Child-Pugh classification and fat mass index. Notably, these indicators deteriorated with disease progression. CONCLUSION: Advanced liver fibrosis leads to the deterioration of many nutritional status parameters. The extent of malnutrition increases with the progression of liver fibrosis. The Child-Pugh score reflects the nutritional status. Baishideng Publishing Group Inc 2023-07-27 2023-07-27 /pmc/articles/PMC10401412/ /pubmed/37547031 http://dx.doi.org/10.4254/wjh.v15.i7.914 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Janota, Barbara
Krupowicz, Aneta
Noras, Kinga
Janczewska, Ewa
Evaluation of the nutritional status of patients with liver cirrhosis
title Evaluation of the nutritional status of patients with liver cirrhosis
title_full Evaluation of the nutritional status of patients with liver cirrhosis
title_fullStr Evaluation of the nutritional status of patients with liver cirrhosis
title_full_unstemmed Evaluation of the nutritional status of patients with liver cirrhosis
title_short Evaluation of the nutritional status of patients with liver cirrhosis
title_sort evaluation of the nutritional status of patients with liver cirrhosis
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401412/
https://www.ncbi.nlm.nih.gov/pubmed/37547031
http://dx.doi.org/10.4254/wjh.v15.i7.914
work_keys_str_mv AT janotabarbara evaluationofthenutritionalstatusofpatientswithlivercirrhosis
AT krupowiczaneta evaluationofthenutritionalstatusofpatientswithlivercirrhosis
AT noraskinga evaluationofthenutritionalstatusofpatientswithlivercirrhosis
AT janczewskaewa evaluationofthenutritionalstatusofpatientswithlivercirrhosis