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Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma
A new variant of intrahepatic cholangiocarcinoma (iCCA) has been recognized in recent years presenting predominantly as a large hepatic mass in young woman with the characteristic expression of inhibin by immunohistochemistry. This variant iCCA was originally termed as cholangioblastic variant of iC...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401414/ https://www.ncbi.nlm.nih.gov/pubmed/37547028 http://dx.doi.org/10.4254/wjh.v15.i7.897 |
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author | González, Iván A Luo, Wenyi Zhang, Xuchen |
author_facet | González, Iván A Luo, Wenyi Zhang, Xuchen |
author_sort | González, Iván A |
collection | PubMed |
description | A new variant of intrahepatic cholangiocarcinoma (iCCA) has been recognized in recent years presenting predominantly as a large hepatic mass in young woman with the characteristic expression of inhibin by immunohistochemistry. This variant iCCA was originally termed as cholangioblastic variant of iCCA, and subsequently proposed to be renamed as inhibin-positive hepatic carcinoma or solid-tubulocystic variant of iCCA to better reflect its immunohistochemical profile or morphologic spectrum. The tumor histologically is composed of small to medium sized cells with scant to moderate amount of eosinophilic cytoplasm heterogeneously organized in solid, tubular, and cystic growth patterns. The tumor cells are positive for biliary markers, inhibin and albumin, and have a novel recurrent gene fusion, NIPBL::NACC1. Awareness of this new iCCA variant and its clinicopathologic features will aid in the diagnostic work-up and avoid confusion with other primary and metastatic hepatic neoplasms. |
format | Online Article Text |
id | pubmed-10401414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-104014142023-08-05 Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma González, Iván A Luo, Wenyi Zhang, Xuchen World J Hepatol Minireviews A new variant of intrahepatic cholangiocarcinoma (iCCA) has been recognized in recent years presenting predominantly as a large hepatic mass in young woman with the characteristic expression of inhibin by immunohistochemistry. This variant iCCA was originally termed as cholangioblastic variant of iCCA, and subsequently proposed to be renamed as inhibin-positive hepatic carcinoma or solid-tubulocystic variant of iCCA to better reflect its immunohistochemical profile or morphologic spectrum. The tumor histologically is composed of small to medium sized cells with scant to moderate amount of eosinophilic cytoplasm heterogeneously organized in solid, tubular, and cystic growth patterns. The tumor cells are positive for biliary markers, inhibin and albumin, and have a novel recurrent gene fusion, NIPBL::NACC1. Awareness of this new iCCA variant and its clinicopathologic features will aid in the diagnostic work-up and avoid confusion with other primary and metastatic hepatic neoplasms. Baishideng Publishing Group Inc 2023-07-27 2023-07-27 /pmc/articles/PMC10401414/ /pubmed/37547028 http://dx.doi.org/10.4254/wjh.v15.i7.897 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews González, Iván A Luo, Wenyi Zhang, Xuchen Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title | Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title_full | Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title_fullStr | Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title_full_unstemmed | Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title_short | Solid-Tubulocystic carcinoma: A new variant of intrahepatic cholangiocarcinoma |
title_sort | solid-tubulocystic carcinoma: a new variant of intrahepatic cholangiocarcinoma |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401414/ https://www.ncbi.nlm.nih.gov/pubmed/37547028 http://dx.doi.org/10.4254/wjh.v15.i7.897 |
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