Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure

Streptococcus suis is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different S. suis serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survi...

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Autores principales: Dolbec, Dominic, Lehoux, Mélanie, Okura, Masatoshi, Takamatsu, Daisuke, Gottschalk, Marcelo, Segura, Mariela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401424/
https://www.ncbi.nlm.nih.gov/pubmed/37545852
http://dx.doi.org/10.3389/fcimb.2023.1228496
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author Dolbec, Dominic
Lehoux, Mélanie
Okura, Masatoshi
Takamatsu, Daisuke
Gottschalk, Marcelo
Segura, Mariela
author_facet Dolbec, Dominic
Lehoux, Mélanie
Okura, Masatoshi
Takamatsu, Daisuke
Gottschalk, Marcelo
Segura, Mariela
author_sort Dolbec, Dominic
collection PubMed
description Streptococcus suis is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different S. suis serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survival in mice, antibody binding, and antibody-mediated bacterial killing. The CPS of serotypes 3, 4 and 14 allowed more antibody binding and bacterial elimination than the CPS of serotypes 2, 7 and 9. Results suggest that the different CPS structures of S. suis provide varying levels of protection by influencing antigen availability and elimination by the host immune system.
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spelling pubmed-104014242023-08-05 Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure Dolbec, Dominic Lehoux, Mélanie Okura, Masatoshi Takamatsu, Daisuke Gottschalk, Marcelo Segura, Mariela Front Cell Infect Microbiol Cellular and Infection Microbiology Streptococcus suis is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different S. suis serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survival in mice, antibody binding, and antibody-mediated bacterial killing. The CPS of serotypes 3, 4 and 14 allowed more antibody binding and bacterial elimination than the CPS of serotypes 2, 7 and 9. Results suggest that the different CPS structures of S. suis provide varying levels of protection by influencing antigen availability and elimination by the host immune system. Frontiers Media S.A. 2023-07-21 /pmc/articles/PMC10401424/ /pubmed/37545852 http://dx.doi.org/10.3389/fcimb.2023.1228496 Text en Copyright © 2023 Dolbec, Lehoux, Okura, Takamatsu, Gottschalk and Segura https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Dolbec, Dominic
Lehoux, Mélanie
Okura, Masatoshi
Takamatsu, Daisuke
Gottschalk, Marcelo
Segura, Mariela
Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title_full Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title_fullStr Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title_full_unstemmed Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title_short Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
title_sort streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401424/
https://www.ncbi.nlm.nih.gov/pubmed/37545852
http://dx.doi.org/10.3389/fcimb.2023.1228496
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