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Intratumoral NKp46(+) natural killer cells are spatially distanced from T and MHC-I(+) cells with prognostic implications in soft tissue sarcoma

INTRODUCTION: Soft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked with favorable outcomes in STS patients, though the contribution of natural killer (NK) cells and spatial relationships of...

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Detalles Bibliográficos
Autores principales:	Cruz, Sylvia M., Sholevar, Cyrus J., Judge, Sean J., Darrow, Morgan A., Iranpur, Khurshid R., Farley, Lauren E., Lammers, Marshall, Razmara, Aryana M., Dunai, Cordelia, Gingrich, Alicia A., Persky, Julia, Mori, Hidetoshi, Thorpe, Steven W., Monjazeb, Arta M., Murphy, William J., Canter, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401426/ https://www.ncbi.nlm.nih.gov/pubmed/37545516 http://dx.doi.org/10.3389/fimmu.2023.1230534

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