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Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery
OBJECTIVES: Subclinical hypothyroidism (SCH) is characterized by an elevated thyroid-stimulating hormone and normal free thyroxine. This study aimed to evaluate the influence of SCH on mid-term outcomes of patients after coronary artery bypass grafting (CABG). METHODS: From January 2015 to December...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401495/ https://www.ncbi.nlm.nih.gov/pubmed/37522881 http://dx.doi.org/10.1093/icvts/ivad120 |
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author | Zhao, Dong Zhao, Wei Wang, Chuangshi Xu, Fei Zhao, Wei Tiemuerniyazi, Xieraili Ma, Hao Feng, Wei |
author_facet | Zhao, Dong Zhao, Wei Wang, Chuangshi Xu, Fei Zhao, Wei Tiemuerniyazi, Xieraili Ma, Hao Feng, Wei |
author_sort | Zhao, Dong |
collection | PubMed |
description | OBJECTIVES: Subclinical hypothyroidism (SCH) is characterized by an elevated thyroid-stimulating hormone and normal free thyroxine. This study aimed to evaluate the influence of SCH on mid-term outcomes of patients after coronary artery bypass grafting (CABG). METHODS: From January 2015 to December 2018, 548 SCH patients and 6718 euthyroid patients who underwent CABG were identified. Propensity score matching was used to create 2 cohorts with similar baseline characteristics (n = 544 in each group). The mid-term follow-up outcomes were compared. Adjusted hazard ratios (HRs) were calculated using Cox proportional hazards models. RESULTS: The mean follow-up for all patients was 39.7 ± 17.3 months. The unadjusted Kaplan–Meier estimate for mortality at 5-year follow-up was higher in patients with SCH compared with euthyroid patients (5.3% vs 1.6%, log-rank P = 0.03). After adjusting for covariates, the risk of mortality was higher in patients with SCH compared with euthyroid patients [HR, 2.40; 95% confidence interval (CI), 1.03–5.58; P = 0.04]. The adjusted risk of major adverse cardiovascular and cerebral event (HR, 2.16; 95% CI, 1.51–3.08; P < 0.001) and angina (HR, 2.44; 95% CI, 1.41–4.24; P = 0.001) was higher in patients with SCH compared with euthyroid patients. CONCLUSIONS: SCH is associated with an increased risk of mortality, major adverse cardiovascular and cerebral event and angina compared with euthyroidism in patients undergoing CABG. |
format | Online Article Text |
id | pubmed-10401495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104014952023-08-05 Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery Zhao, Dong Zhao, Wei Wang, Chuangshi Xu, Fei Zhao, Wei Tiemuerniyazi, Xieraili Ma, Hao Feng, Wei Interdiscip Cardiovasc Thorac Surg Coronary Disease OBJECTIVES: Subclinical hypothyroidism (SCH) is characterized by an elevated thyroid-stimulating hormone and normal free thyroxine. This study aimed to evaluate the influence of SCH on mid-term outcomes of patients after coronary artery bypass grafting (CABG). METHODS: From January 2015 to December 2018, 548 SCH patients and 6718 euthyroid patients who underwent CABG were identified. Propensity score matching was used to create 2 cohorts with similar baseline characteristics (n = 544 in each group). The mid-term follow-up outcomes were compared. Adjusted hazard ratios (HRs) were calculated using Cox proportional hazards models. RESULTS: The mean follow-up for all patients was 39.7 ± 17.3 months. The unadjusted Kaplan–Meier estimate for mortality at 5-year follow-up was higher in patients with SCH compared with euthyroid patients (5.3% vs 1.6%, log-rank P = 0.03). After adjusting for covariates, the risk of mortality was higher in patients with SCH compared with euthyroid patients [HR, 2.40; 95% confidence interval (CI), 1.03–5.58; P = 0.04]. The adjusted risk of major adverse cardiovascular and cerebral event (HR, 2.16; 95% CI, 1.51–3.08; P < 0.001) and angina (HR, 2.44; 95% CI, 1.41–4.24; P = 0.001) was higher in patients with SCH compared with euthyroid patients. CONCLUSIONS: SCH is associated with an increased risk of mortality, major adverse cardiovascular and cerebral event and angina compared with euthyroidism in patients undergoing CABG. Oxford University Press 2023-07-31 /pmc/articles/PMC10401495/ /pubmed/37522881 http://dx.doi.org/10.1093/icvts/ivad120 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Coronary Disease Zhao, Dong Zhao, Wei Wang, Chuangshi Xu, Fei Zhao, Wei Tiemuerniyazi, Xieraili Ma, Hao Feng, Wei Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title | Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title_full | Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title_fullStr | Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title_full_unstemmed | Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title_short | Mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
title_sort | mid-term outcomes of patients with subclinical hypothyroidism after coronary bypass surgery |
topic | Coronary Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401495/ https://www.ncbi.nlm.nih.gov/pubmed/37522881 http://dx.doi.org/10.1093/icvts/ivad120 |
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