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Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
[Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401507/ https://www.ncbi.nlm.nih.gov/pubmed/37480156 http://dx.doi.org/10.1021/acsami.3c06139 |
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author | Mikulchyk, Tatsiana Walsh, John Browne, Jacinta Naydenova, Izabela Cody, Dervil |
author_facet | Mikulchyk, Tatsiana Walsh, John Browne, Jacinta Naydenova, Izabela Cody, Dervil |
author_sort | Mikulchyk, Tatsiana |
collection | PubMed |
description | [Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point of maximum acoustic pressure) on the hologram’s response has been investigated for two types of therapeutic ultrasound systems: a sonoporation system and an ultrasound physiotherapy system. Findings show that, above a switching temperature of 45 °C, the ultrasound-induced temperature rise produces a structural change in the hologram, which manifests as a visible color change. The area of the color change region correlates with the ultrasound exposure conditions. The suitability of the hologram as a simple and quick QA test tool for therapeutic ultrasound systems has been demonstrated. A prototype ultrasound testing unit which facilitates user-friendly, reproducible testing of the holograms in a clinical setting is also reported. |
format | Online Article Text |
id | pubmed-10401507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-104015072023-08-05 Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems Mikulchyk, Tatsiana Walsh, John Browne, Jacinta Naydenova, Izabela Cody, Dervil ACS Appl Mater Interfaces [Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point of maximum acoustic pressure) on the hologram’s response has been investigated for two types of therapeutic ultrasound systems: a sonoporation system and an ultrasound physiotherapy system. Findings show that, above a switching temperature of 45 °C, the ultrasound-induced temperature rise produces a structural change in the hologram, which manifests as a visible color change. The area of the color change region correlates with the ultrasound exposure conditions. The suitability of the hologram as a simple and quick QA test tool for therapeutic ultrasound systems has been demonstrated. A prototype ultrasound testing unit which facilitates user-friendly, reproducible testing of the holograms in a clinical setting is also reported. American Chemical Society 2023-07-21 /pmc/articles/PMC10401507/ /pubmed/37480156 http://dx.doi.org/10.1021/acsami.3c06139 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Mikulchyk, Tatsiana Walsh, John Browne, Jacinta Naydenova, Izabela Cody, Dervil Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems |
title | Color-Changing
Reflection Hologram for Quality Assurance
of Therapeutic Ultrasound Systems |
title_full | Color-Changing
Reflection Hologram for Quality Assurance
of Therapeutic Ultrasound Systems |
title_fullStr | Color-Changing
Reflection Hologram for Quality Assurance
of Therapeutic Ultrasound Systems |
title_full_unstemmed | Color-Changing
Reflection Hologram for Quality Assurance
of Therapeutic Ultrasound Systems |
title_short | Color-Changing
Reflection Hologram for Quality Assurance
of Therapeutic Ultrasound Systems |
title_sort | color-changing
reflection hologram for quality assurance
of therapeutic ultrasound systems |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401507/ https://www.ncbi.nlm.nih.gov/pubmed/37480156 http://dx.doi.org/10.1021/acsami.3c06139 |
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