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Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems

[Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A...

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Autores principales: Mikulchyk, Tatsiana, Walsh, John, Browne, Jacinta, Naydenova, Izabela, Cody, Dervil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401507/
https://www.ncbi.nlm.nih.gov/pubmed/37480156
http://dx.doi.org/10.1021/acsami.3c06139
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author Mikulchyk, Tatsiana
Walsh, John
Browne, Jacinta
Naydenova, Izabela
Cody, Dervil
author_facet Mikulchyk, Tatsiana
Walsh, John
Browne, Jacinta
Naydenova, Izabela
Cody, Dervil
author_sort Mikulchyk, Tatsiana
collection PubMed
description [Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point of maximum acoustic pressure) on the hologram’s response has been investigated for two types of therapeutic ultrasound systems: a sonoporation system and an ultrasound physiotherapy system. Findings show that, above a switching temperature of 45 °C, the ultrasound-induced temperature rise produces a structural change in the hologram, which manifests as a visible color change. The area of the color change region correlates with the ultrasound exposure conditions. The suitability of the hologram as a simple and quick QA test tool for therapeutic ultrasound systems has been demonstrated. A prototype ultrasound testing unit which facilitates user-friendly, reproducible testing of the holograms in a clinical setting is also reported.
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spelling pubmed-104015072023-08-05 Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems Mikulchyk, Tatsiana Walsh, John Browne, Jacinta Naydenova, Izabela Cody, Dervil ACS Appl Mater Interfaces [Image: see text] The acoustic output of clinical therapeutic ultrasound equipment requires regular quality assurance (QA) testing to ensure the safety and efficacy of the treatment and that any potentially harmful deviations from the expected output power density are detected as soon as possible. A hologram, consisting of a reflection grating fabricated in an acrylate photopolymer film, has been developed to produce an immediate, visible, and permanent change in the color of the reconstructed hologram from red to green in response to incident ultrasound energy. The influence of the therapeutic ultrasound insonation parameters (exposure time, ultrasound power density, and proximity to the point of maximum acoustic pressure) on the hologram’s response has been investigated for two types of therapeutic ultrasound systems: a sonoporation system and an ultrasound physiotherapy system. Findings show that, above a switching temperature of 45 °C, the ultrasound-induced temperature rise produces a structural change in the hologram, which manifests as a visible color change. The area of the color change region correlates with the ultrasound exposure conditions. The suitability of the hologram as a simple and quick QA test tool for therapeutic ultrasound systems has been demonstrated. A prototype ultrasound testing unit which facilitates user-friendly, reproducible testing of the holograms in a clinical setting is also reported. American Chemical Society 2023-07-21 /pmc/articles/PMC10401507/ /pubmed/37480156 http://dx.doi.org/10.1021/acsami.3c06139 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Mikulchyk, Tatsiana
Walsh, John
Browne, Jacinta
Naydenova, Izabela
Cody, Dervil
Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title_full Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title_fullStr Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title_full_unstemmed Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title_short Color-Changing Reflection Hologram for Quality Assurance of Therapeutic Ultrasound Systems
title_sort color-changing reflection hologram for quality assurance of therapeutic ultrasound systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401507/
https://www.ncbi.nlm.nih.gov/pubmed/37480156
http://dx.doi.org/10.1021/acsami.3c06139
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