Refractory pancytopenia upon initiation of asciminib in tyrosine kinase inhibitor-resistant chronic myeloid leukemia

Asciminib, a “Specifically Targeting the ABL Myristoyl Pocket” inhibitor, is a new drug in the treatment of tyrosine kinase inhibitor (TKI)-resistant chronic myeloid leukemia (CML). Hemocytopenias associated with asciminib are common adverse events documented by clinical trials. We report a case of...

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Detalles Bibliográficos
Autores principales: Tessier, Steven, Aiad, Mina, Longo, Santo, Wilson, Melissa, Faroun, Yacoub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401557/
https://www.ncbi.nlm.nih.gov/pubmed/37547190
http://dx.doi.org/10.4103/ijciis.ijciis_85_22
Descripción
Sumario:Asciminib, a “Specifically Targeting the ABL Myristoyl Pocket” inhibitor, is a new drug in the treatment of tyrosine kinase inhibitor (TKI)-resistant chronic myeloid leukemia (CML). Hemocytopenias associated with asciminib are common adverse events documented by clinical trials. We report a case of precipitous-onset pancytopenia with the initiation of asciminib treatment in a patient with TKI-resistant CML. This case had a confounding array of laboratory findings that evidenced a drug-induced hemophagocytic component. We hope that our case stimulates further reporting of similar cases to enhance the understanding of the pathophysiology underlying asciminib-induced hemocytopenias.