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Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
[Image: see text] A family of chiral iodoaniline-lactate based catalysts with C(1) and C(2) symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of keton...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401694/ https://www.ncbi.nlm.nih.gov/pubmed/37545658 http://dx.doi.org/10.1021/acsorginorgau.3c00012 |
| Sumario: | [Image: see text] A family of chiral iodoaniline-lactate based catalysts with C(1) and C(2) symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%. |
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