Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones

[Image: see text] A family of chiral iodoaniline-lactate based catalysts with C(1) and C(2) symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of keton...

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Autores principales: Alkahtani, Rawiyah, Wirth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401694/
https://www.ncbi.nlm.nih.gov/pubmed/37545658
http://dx.doi.org/10.1021/acsorginorgau.3c00012
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author Alkahtani, Rawiyah
Wirth, Thomas
author_facet Alkahtani, Rawiyah
Wirth, Thomas
author_sort Alkahtani, Rawiyah
collection PubMed
description [Image: see text] A family of chiral iodoaniline-lactate based catalysts with C(1) and C(2) symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%.
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spelling pubmed-104016942023-08-05 Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones Alkahtani, Rawiyah Wirth, Thomas ACS Org Inorg Au [Image: see text] A family of chiral iodoaniline-lactate based catalysts with C(1) and C(2) symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%. American Chemical Society 2023-05-09 /pmc/articles/PMC10401694/ /pubmed/37545658 http://dx.doi.org/10.1021/acsorginorgau.3c00012 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Alkahtani, Rawiyah
Wirth, Thomas
Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title_full Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title_fullStr Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title_full_unstemmed Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title_short Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones
title_sort synthesis of chiral iodoaniline-lactate based catalysts for the α-functionalization of ketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401694/
https://www.ncbi.nlm.nih.gov/pubmed/37545658
http://dx.doi.org/10.1021/acsorginorgau.3c00012
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