Novel scheme for defining the clinical implications of TP53 mutations in myeloid neoplasia

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BACKGROUND: TP53 mutations (TP53(MT)) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence of cryptic biallelic subclones in cas...

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Detalles Bibliográficos
Autores principales: Bahaj, Waled, Kewan, Tariq, Gurnari, Carmelo, Durmaz, Arda, Ponvilawan, Ben, Pandit, Ishani, Kubota, Yasuo, Ogbue, Olisaemeka D., Zawit, Misam, Madanat, Yazan, Bat, Taha, Balasubramanian, Suresh K., Awada, Hussein, Ahmed, Ramsha, Mori, Minako, Meggendorfer, Manja, Haferlach, Torsten, Visconte, Valeria, Maciejewski, Jaroslaw P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401750/
https://www.ncbi.nlm.nih.gov/pubmed/37537667
http://dx.doi.org/10.1186/s13045-023-01480-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401750/
https://www.ncbi.nlm.nih.gov/pubmed/37537667
http://dx.doi.org/10.1186/s13045-023-01480-y

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