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New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
Lymph nodes targeted drug delivery is an attractive approach to improve cancer immunotherapy outcomes. Currently, the depth of understanding of afferent and efferent arms in brain immunity reveals the potential clinical applications of lymph node targeted drug delivery in brain tumors, e.g., gliobla...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401854/ https://www.ncbi.nlm.nih.gov/pubmed/37542241 http://dx.doi.org/10.1186/s12951-023-02011-0 |
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author | Qi, Yangzhi Xiong, Wei Chen, Qianxue Ye, Zhifei Jiang, Cailei He, Yan Ye, Qingsong |
author_facet | Qi, Yangzhi Xiong, Wei Chen, Qianxue Ye, Zhifei Jiang, Cailei He, Yan Ye, Qingsong |
author_sort | Qi, Yangzhi |
collection | PubMed |
description | Lymph nodes targeted drug delivery is an attractive approach to improve cancer immunotherapy outcomes. Currently, the depth of understanding of afferent and efferent arms in brain immunity reveals the potential clinical applications of lymph node targeted drug delivery in brain tumors, e.g., glioblastoma. In this work, we systematically reviewed the microenvironment of glioblastoma and its structure as a basis for potential immunotherapy, including the glial-lymphatic pathway for substance exchange, the lymphatic drainage pathway from meningeal lymphatic vessels to deep cervical lymph nodes that communicate intra- and extracranial immunity, and the interaction between the blood–brain barrier and effector T cells. Furthermore, the carriers designed for lymph nodes targeted drug delivery were comprehensively summarized. The challenges and opportunities in developing a lymph nodes targeted delivery strategy for glioblastoma using nanotechnology are included at the end. |
format | Online Article Text |
id | pubmed-10401854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104018542023-08-05 New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery Qi, Yangzhi Xiong, Wei Chen, Qianxue Ye, Zhifei Jiang, Cailei He, Yan Ye, Qingsong J Nanobiotechnology Review Lymph nodes targeted drug delivery is an attractive approach to improve cancer immunotherapy outcomes. Currently, the depth of understanding of afferent and efferent arms in brain immunity reveals the potential clinical applications of lymph node targeted drug delivery in brain tumors, e.g., glioblastoma. In this work, we systematically reviewed the microenvironment of glioblastoma and its structure as a basis for potential immunotherapy, including the glial-lymphatic pathway for substance exchange, the lymphatic drainage pathway from meningeal lymphatic vessels to deep cervical lymph nodes that communicate intra- and extracranial immunity, and the interaction between the blood–brain barrier and effector T cells. Furthermore, the carriers designed for lymph nodes targeted drug delivery were comprehensively summarized. The challenges and opportunities in developing a lymph nodes targeted delivery strategy for glioblastoma using nanotechnology are included at the end. BioMed Central 2023-08-04 /pmc/articles/PMC10401854/ /pubmed/37542241 http://dx.doi.org/10.1186/s12951-023-02011-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Qi, Yangzhi Xiong, Wei Chen, Qianxue Ye, Zhifei Jiang, Cailei He, Yan Ye, Qingsong New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title | New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title_full | New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title_fullStr | New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title_full_unstemmed | New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title_short | New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
title_sort | new trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401854/ https://www.ncbi.nlm.nih.gov/pubmed/37542241 http://dx.doi.org/10.1186/s12951-023-02011-0 |
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