The role of organoids in cancer research

Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valua...

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Detalles Bibliográficos
Autores principales: Fang, Zhen, Li, Peijuan, Du, Fengying, Shang, Liang, Li, Leping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401879/
https://www.ncbi.nlm.nih.gov/pubmed/37537666
http://dx.doi.org/10.1186/s40164-023-00433-y
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author Fang, Zhen
Li, Peijuan
Du, Fengying
Shang, Liang
Li, Leping
author_facet Fang, Zhen
Li, Peijuan
Du, Fengying
Shang, Liang
Li, Leping
author_sort Fang, Zhen
collection PubMed
description Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valuable preclinical model for academic research and personalized medicine. A number of studies have confirmed that organoids have great application prospects in new drug development, drug screening, tumour mechanism research, and precision medicine. In this review, we mainly focus on recent advances in the application of organoids in cancer research. We also discussed the opportunities and challenges facing organoids, hoping to indicate directions for the development of organoids in the future.
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spelling pubmed-104018792023-08-05 The role of organoids in cancer research Fang, Zhen Li, Peijuan Du, Fengying Shang, Liang Li, Leping Exp Hematol Oncol Review Organoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valuable preclinical model for academic research and personalized medicine. A number of studies have confirmed that organoids have great application prospects in new drug development, drug screening, tumour mechanism research, and precision medicine. In this review, we mainly focus on recent advances in the application of organoids in cancer research. We also discussed the opportunities and challenges facing organoids, hoping to indicate directions for the development of organoids in the future. BioMed Central 2023-08-03 /pmc/articles/PMC10401879/ /pubmed/37537666 http://dx.doi.org/10.1186/s40164-023-00433-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fang, Zhen
Li, Peijuan
Du, Fengying
Shang, Liang
Li, Leping
The role of organoids in cancer research
title The role of organoids in cancer research
title_full The role of organoids in cancer research
title_fullStr The role of organoids in cancer research
title_full_unstemmed The role of organoids in cancer research
title_short The role of organoids in cancer research
title_sort role of organoids in cancer research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401879/
https://www.ncbi.nlm.nih.gov/pubmed/37537666
http://dx.doi.org/10.1186/s40164-023-00433-y
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