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Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections

BACKGROUND: Invasive infections with beta-haemolytic streptococci of Lancefield groups A (iGAS), B (iGBS) and C/G (iGCGS) are a major cause of morbidity and mortality worldwide. AIM: We studied incidence trends of invasive beta-haemolytic streptococcal infections in Finland, focusing on iGCGS. METHO...

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Autores principales: Paspaliari, Dafni Katerina, Sarvikivi, Emmi, Ollgren, Jukka, Vuopio, Jaana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401913/
https://www.ncbi.nlm.nih.gov/pubmed/37535473
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.31.2200807
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author Paspaliari, Dafni Katerina
Sarvikivi, Emmi
Ollgren, Jukka
Vuopio, Jaana
author_facet Paspaliari, Dafni Katerina
Sarvikivi, Emmi
Ollgren, Jukka
Vuopio, Jaana
author_sort Paspaliari, Dafni Katerina
collection PubMed
description BACKGROUND: Invasive infections with beta-haemolytic streptococci of Lancefield groups A (iGAS), B (iGBS) and C/G (iGCGS) are a major cause of morbidity and mortality worldwide. AIM: We studied incidence trends of invasive beta-haemolytic streptococcal infections in Finland, focusing on iGCGS. METHODS: We conducted a retrospective register-based study. Cases were defined as isolations from blood and/or cerebrospinal fluid and retrieved from the National Infectious Disease Register where all invasive cases are mandatorily notified. RESULTS: Between 2006 and 2020, the mean annual incidence was 4.1 per 100,000 for iGAS (range: 2.1–6.7), 5.2 for iGBS (4.0–6.3) and 10.1 for iGCGS (5.4–17.6). The incidence displayed an increasing trend for all groups, albeit for iGBS only for individuals 45 years and older. The increase was particularly sharp for iGCGS (8% annual relative increase). The incidence rate was higher in males for iGCGS (adjusted incidence rate ratio (IRR) = 1.6; 95% confidence interval (CI): 1.5–1.8) and iGAS (adjusted IRR = 1.3; 95% CI: 1.1–1.4); for iGBS, the association with sex was age-dependent. In adults, iGCGS incidence increased significantly with age. Recurrency was seen for iGCGS and secondarily iGBS, but not for iGAS. Infections with iGCGS and iGBS peaked in July and August. CONCLUSIONS: The incidence of invasive beta-haemolytic streptococcal infections in Finland has been rising since 2006, especially for iGCGS and among the elderly population. However, national surveillance still focuses on iGAS and iGBS, and European Union-wide surveillance is lacking. We recommend that surveillance of iGCGS be enhanced, including systematic collection and typing of isolates, to guide infection prevention strategies.
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spelling pubmed-104019132023-08-05 Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections Paspaliari, Dafni Katerina Sarvikivi, Emmi Ollgren, Jukka Vuopio, Jaana Euro Surveill Surveillance BACKGROUND: Invasive infections with beta-haemolytic streptococci of Lancefield groups A (iGAS), B (iGBS) and C/G (iGCGS) are a major cause of morbidity and mortality worldwide. AIM: We studied incidence trends of invasive beta-haemolytic streptococcal infections in Finland, focusing on iGCGS. METHODS: We conducted a retrospective register-based study. Cases were defined as isolations from blood and/or cerebrospinal fluid and retrieved from the National Infectious Disease Register where all invasive cases are mandatorily notified. RESULTS: Between 2006 and 2020, the mean annual incidence was 4.1 per 100,000 for iGAS (range: 2.1–6.7), 5.2 for iGBS (4.0–6.3) and 10.1 for iGCGS (5.4–17.6). The incidence displayed an increasing trend for all groups, albeit for iGBS only for individuals 45 years and older. The increase was particularly sharp for iGCGS (8% annual relative increase). The incidence rate was higher in males for iGCGS (adjusted incidence rate ratio (IRR) = 1.6; 95% confidence interval (CI): 1.5–1.8) and iGAS (adjusted IRR = 1.3; 95% CI: 1.1–1.4); for iGBS, the association with sex was age-dependent. In adults, iGCGS incidence increased significantly with age. Recurrency was seen for iGCGS and secondarily iGBS, but not for iGAS. Infections with iGCGS and iGBS peaked in July and August. CONCLUSIONS: The incidence of invasive beta-haemolytic streptococcal infections in Finland has been rising since 2006, especially for iGCGS and among the elderly population. However, national surveillance still focuses on iGAS and iGBS, and European Union-wide surveillance is lacking. We recommend that surveillance of iGCGS be enhanced, including systematic collection and typing of isolates, to guide infection prevention strategies. European Centre for Disease Prevention and Control (ECDC) 2023-08-03 /pmc/articles/PMC10401913/ /pubmed/37535473 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.31.2200807 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance
Paspaliari, Dafni Katerina
Sarvikivi, Emmi
Ollgren, Jukka
Vuopio, Jaana
Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title_full Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title_fullStr Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title_full_unstemmed Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title_short Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections
title_sort invasive beta-haemolytic streptococcal infections, finland, 2006 to 2020: increase in lancefield group c/g infections
topic Surveillance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401913/
https://www.ncbi.nlm.nih.gov/pubmed/37535473
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.31.2200807
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