APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

Several genetic risk factors for Alzheimer’s Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Through single-nucleus RNA-...

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Detalles Bibliográficos
Autores principales: Haney, Michael S., Pálovics, Róbert, Munson, Christy Nicole, Long, Chris, Johansson, Patrik, Yip, Oscar, Dong, Wentao, Rawat, Eshaan, West, Elizabeth, Schlachetzki, Johannes CM, Tsai, Andy, Guldner, Ian Hunter, Lamichhane, Bhawika S., Smith, Amanda, Schaum, Nicholas, Calcuttawala, Kruti, Shin, Andrew, Wang, Yung-Hua, Wang, Chengzhong, Koutsodendris, Nicole, Serrano, Geidy E, Beach, Thomas G, Reiman, Eric M, Glass, Christopher K, Abu-Remaileh, Monther, Enejder, Annika, Huang, Yadong, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401952/
https://www.ncbi.nlm.nih.gov/pubmed/37546938
http://dx.doi.org/10.1101/2023.07.21.549930

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