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Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin Activity

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Cholesterol dependent cytolysins (CDCs) are a large family of pore forming toxins, produced by numerous gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface associated human CD59 (hCD59) for binding, conferring specificity for human cel...

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Detalles Bibliográficos
Autores principales:	Shahi, Ifrah, Dongas, Sophia A., Ilmain, Juliana K., Torres, Victor J., Ratner, Adam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401958/ https://www.ncbi.nlm.nih.gov/pubmed/37546867 http://dx.doi.org/10.1101/2023.06.21.545930

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