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ClusterDE: a post-clustering differential expression (DE) method robust to false-positive inflation caused by double dipping

In typical single-cell RNA-seq (scRNA-seq) data analysis, a clustering algorithm is applied to find putative cell types as clusters, and then a statistical differential expression (DE) test is used to identify the differentially expressed (DE) genes between the cell clusters. However, this common pr...

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Detalles Bibliográficos
Autores principales: Song, Dongyuan, Li, Kexin, Ge, Xinzhou, Li, Jingyi Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401959/
https://www.ncbi.nlm.nih.gov/pubmed/37546812
http://dx.doi.org/10.1101/2023.07.21.550107