In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

Homology Directed Repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differentiated tissues. Here, we tested “Repair Drive”, a novel method...

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Detalles Bibliográficos
Autores principales: De Giorgi, Marco, Park, So Hyun, Castoreno, Adam, Cao, Mingming, Hurley, Ayrea, Saxena, Lavanya, Chuecos, Marcel A., Walkey, Christopher J., Doerfler, Alexandria M., Furgurson, Mia N., Ljungberg, M. Cecilia, Patel, Kalyani R., Hyde, Sarah, Chickering, Tyler, Lefebvre, Stephanie, Wassarman, Kelly, Miller, Patrick, Qin, June, Schlegel, Mark K., Zlatev, Ivan, Li, Rich Gang, Kim, Jong, Martin, James F., Bissig, Karl-Dimiter, Jadhav, Vasant, Bao, Gang, Lagor, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402145/
https://www.ncbi.nlm.nih.gov/pubmed/37546995
http://dx.doi.org/10.1101/2023.07.26.550728

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