Cargando…
H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance
In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For 30 years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been hotly debated. We found that, u...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402168/ https://www.ncbi.nlm.nih.gov/pubmed/37546937 http://dx.doi.org/10.1101/2023.07.27.550865 |
_version_ | 1785084813299941376 |
---|---|
author | Cao, Lijun Yoo, Heejin Chen, Tianyuan Mwimba, Musoki Zhang, Xing Dong, Xinnian |
author_facet | Cao, Lijun Yoo, Heejin Chen, Tianyuan Mwimba, Musoki Zhang, Xing Dong, Xinnian |
author_sort | Cao, Lijun |
collection | PubMed |
description | In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For 30 years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been hotly debated. We found that, upon pathogen challenge, the cysteine residue of transcription factor CHE undergoes sulfenylation in systemic tissues, enhancing its binding to the promoter of SA-synthesis gene, ICS1, and increasing SA production. This occurs independently of previously reported pipecolic acid (Pip) signal. Instead, H(2)O(2) produced by NADPH oxidase, RBOHD, is the mobile signal that sulfenylates CHE in a concentration-dependent manner. This modification serves as a molecular switch that activates CHE-mediated SA-increase and subsequent Pip-accumulation in systemic tissues to synergistically induce SAR. |
format | Online Article Text |
id | pubmed-10402168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-104021682023-08-05 H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance Cao, Lijun Yoo, Heejin Chen, Tianyuan Mwimba, Musoki Zhang, Xing Dong, Xinnian bioRxiv Article In plants, a local infection can lead to systemic acquired resistance (SAR) through increased production of salicylic acid (SA). For 30 years, the identity of the mobile signal and its direct transduction mechanism for systemic SA synthesis in initiating SAR have been hotly debated. We found that, upon pathogen challenge, the cysteine residue of transcription factor CHE undergoes sulfenylation in systemic tissues, enhancing its binding to the promoter of SA-synthesis gene, ICS1, and increasing SA production. This occurs independently of previously reported pipecolic acid (Pip) signal. Instead, H(2)O(2) produced by NADPH oxidase, RBOHD, is the mobile signal that sulfenylates CHE in a concentration-dependent manner. This modification serves as a molecular switch that activates CHE-mediated SA-increase and subsequent Pip-accumulation in systemic tissues to synergistically induce SAR. Cold Spring Harbor Laboratory 2023-08-01 /pmc/articles/PMC10402168/ /pubmed/37546937 http://dx.doi.org/10.1101/2023.07.27.550865 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Cao, Lijun Yoo, Heejin Chen, Tianyuan Mwimba, Musoki Zhang, Xing Dong, Xinnian H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title | H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title_full | H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title_fullStr | H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title_full_unstemmed | H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title_short | H(2)O(2) sulfenylates CHE linking local infection to establishment of systemic acquired resistance |
title_sort | h(2)o(2) sulfenylates che linking local infection to establishment of systemic acquired resistance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402168/ https://www.ncbi.nlm.nih.gov/pubmed/37546937 http://dx.doi.org/10.1101/2023.07.27.550865 |
work_keys_str_mv | AT caolijun h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance AT yooheejin h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance AT chentianyuan h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance AT mwimbamusoki h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance AT zhangxing h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance AT dongxinnian h2o2sulfenylateschelinkinglocalinfectiontoestablishmentofsystemicacquiredresistance |