Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer’s disease (AD) therapy. FCER1G is a component of Fc receptor complexes that contain an immunoreceptor tyrosi...

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Detalles Bibliográficos
Autores principales: Bashore, Frances M., Katis, Vittorio L., Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J., Rygiel, Karolina A., Leisner, Tina M., Chalk, Rod, Mishra, Swati, Williams, Andrew C., Gileadi, Opher, Brennan, Paul E., Wiley, Jesse C., Gockley, Jake, Cary, Gregory A., Carter, Gregory W., Young, Jessica E., Pearce, Kenneth H., Fu, Haian, Axtman, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402180/
https://www.ncbi.nlm.nih.gov/pubmed/37547005
http://dx.doi.org/10.1101/2023.07.28.551026

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