Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier

BACKGROUND: Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HIV suppression. These proteins are modulated by demographic and lifestyle factor...

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Detalles Bibliográficos
Autores principales: Fridman, Lisa B., Knerler, Stephen, Price, Amira-Storm, Ortiz, Rodnie Colón, Mercado, Alicia, Wilkins, Hannah, Flores, Bianca R., Orsburn, Benjamin C., Williams, Dionna W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402182/
https://www.ncbi.nlm.nih.gov/pubmed/37546800
http://dx.doi.org/10.1101/2023.07.28.551042

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