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Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis

Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally disti...

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Autores principales: Raleigh, David, Mirchia, Kanish, Choudhury, Abrar, Joseph, Tara, Birrueta, Janeth, Phillips, Joanna, Bhaduri, Aparna, Crouch, Elizabeth, Perry, Arie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402198/
https://www.ncbi.nlm.nih.gov/pubmed/37546798
http://dx.doi.org/10.21203/rs.3.rs-3164953/v1
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author Raleigh, David
Mirchia, Kanish
Choudhury, Abrar
Joseph, Tara
Birrueta, Janeth
Phillips, Joanna
Bhaduri, Aparna
Crouch, Elizabeth
Perry, Arie
author_facet Raleigh, David
Mirchia, Kanish
Choudhury, Abrar
Joseph, Tara
Birrueta, Janeth
Phillips, Joanna
Bhaduri, Aparna
Crouch, Elizabeth
Perry, Arie
author_sort Raleigh, David
collection PubMed
description Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues.
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spelling pubmed-104021982023-08-05 Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis Raleigh, David Mirchia, Kanish Choudhury, Abrar Joseph, Tara Birrueta, Janeth Phillips, Joanna Bhaduri, Aparna Crouch, Elizabeth Perry, Arie Res Sq Article Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues. American Journal Experts 2023-07-26 /pmc/articles/PMC10402198/ /pubmed/37546798 http://dx.doi.org/10.21203/rs.3.rs-3164953/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Raleigh, David
Mirchia, Kanish
Choudhury, Abrar
Joseph, Tara
Birrueta, Janeth
Phillips, Joanna
Bhaduri, Aparna
Crouch, Elizabeth
Perry, Arie
Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title_full Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title_fullStr Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title_full_unstemmed Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title_short Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
title_sort meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402198/
https://www.ncbi.nlm.nih.gov/pubmed/37546798
http://dx.doi.org/10.21203/rs.3.rs-3164953/v1
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