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Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally disti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402198/ https://www.ncbi.nlm.nih.gov/pubmed/37546798 http://dx.doi.org/10.21203/rs.3.rs-3164953/v1 |
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author | Raleigh, David Mirchia, Kanish Choudhury, Abrar Joseph, Tara Birrueta, Janeth Phillips, Joanna Bhaduri, Aparna Crouch, Elizabeth Perry, Arie |
author_facet | Raleigh, David Mirchia, Kanish Choudhury, Abrar Joseph, Tara Birrueta, Janeth Phillips, Joanna Bhaduri, Aparna Crouch, Elizabeth Perry, Arie |
author_sort | Raleigh, David |
collection | PubMed |
description | Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues. |
format | Online Article Text |
id | pubmed-10402198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Journal Experts |
record_format | MEDLINE/PubMed |
spelling | pubmed-104021982023-08-05 Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis Raleigh, David Mirchia, Kanish Choudhury, Abrar Joseph, Tara Birrueta, Janeth Phillips, Joanna Bhaduri, Aparna Crouch, Elizabeth Perry, Arie Res Sq Article Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues. American Journal Experts 2023-07-26 /pmc/articles/PMC10402198/ /pubmed/37546798 http://dx.doi.org/10.21203/rs.3.rs-3164953/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Raleigh, David Mirchia, Kanish Choudhury, Abrar Joseph, Tara Birrueta, Janeth Phillips, Joanna Bhaduri, Aparna Crouch, Elizabeth Perry, Arie Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title | Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title_full | Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title_fullStr | Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title_full_unstemmed | Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title_short | Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
title_sort | meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402198/ https://www.ncbi.nlm.nih.gov/pubmed/37546798 http://dx.doi.org/10.21203/rs.3.rs-3164953/v1 |
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