APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s Disease pathology

The ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor for sporadic Alzheimer’s Disease (AD). Knockdown of this allele may provide a therapeutic strategy for AD, but the effect of APOE loss-of-function (LoF) on AD pathogenesis is unknown. We searched for APOE LoF variants in a...

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Detalles Bibliográficos
Autores principales: Chemparathy, Augustine, Guen, Yann Le, Chen, Sunny, Lee, Eun-Gyung, Leong, Lesley, Gorzynski, John, Xu, Guangxue, Belloy, Michael, Kasireddy, Nandita, Tauber, Andrés Peña, Williams, Kennedy, Stewart, Ilaria, Wingo, Thomas, Lah, James, Jayadev, Suman, Hales, Chad, Peskind, Elaine, Child, Daniel D, Keene, C Dirk, Cong, Le, Ashley, Euan, Yu, Chang-En, Greicius, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402217/
https://www.ncbi.nlm.nih.gov/pubmed/37547016
http://dx.doi.org/10.1101/2023.07.20.23292771

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