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Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity

The HIV/AIDS epidemic remains critical in sub-Saharan Africa, with UNAIDS establishing “95-95-95” targets to optimize HIV care. Using the Zimbabwe Population-based HIV Impact Assessment (ZIMPHIA) geospatial data, this study aimed to identify patterns in these targets and determinants impacting the H...

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Autores principales: Chowdhury, MD Tuhin, Bershteyn, Anna, Milali, Masabho, Citron, Daniel, Nyimbili, Sulani, Musuka, Godfrey, Cuadros, Diego F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402226/
https://www.ncbi.nlm.nih.gov/pubmed/37546877
http://dx.doi.org/10.1101/2023.07.26.23293207
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author Chowdhury, MD Tuhin
Bershteyn, Anna
Milali, Masabho
Citron, Daniel
Nyimbili, Sulani
Musuka, Godfrey
Cuadros, Diego F
author_facet Chowdhury, MD Tuhin
Bershteyn, Anna
Milali, Masabho
Citron, Daniel
Nyimbili, Sulani
Musuka, Godfrey
Cuadros, Diego F
author_sort Chowdhury, MD Tuhin
collection PubMed
description The HIV/AIDS epidemic remains critical in sub-Saharan Africa, with UNAIDS establishing “95-95-95” targets to optimize HIV care. Using the Zimbabwe Population-based HIV Impact Assessment (ZIMPHIA) geospatial data, this study aimed to identify patterns in these targets and determinants impacting the HIV care continuum in underserved Zimbabwean communities. Analysis techniques, including Gaussian kernel interpolation, optimized hotspot, and multivariate geospatial k-means clustering, were utilized to establish spatial patterns and cluster regional HIV care continuum needs. Further, we investigated healthcare availability, access, and social determinants and scrutinized the association between socio-demographic and behavioral covariates with HIV care outcomes. Disparities in progress toward the “95-95-95” targets were noted across different regions, with each target demonstrating unique geographic patterns, resulting in four distinct clusters with specific HIV care needs. Key factors associated with gaps in achieving targets included younger age, male sex, employment, and minority or no religious affiliation. Our study uncovers significant spatial heterogeneity in the HIV care continuum in Zimbabwe, with unique regional patterns in “95-95-95” targets. The spatial analysis of the UNAIDS targets presented here could prove instrumental in designing effective control strategies by identifying vulnerable communities that are falling short of these targets and require intensified efforts. Our result provides insights for designing region-specific interventions and enhancing community-level factors, emphasizing the need to address regional gaps and improve HIV care outcomes in vulnerable communities lagging behind.
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spelling pubmed-104022262023-08-05 Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity Chowdhury, MD Tuhin Bershteyn, Anna Milali, Masabho Citron, Daniel Nyimbili, Sulani Musuka, Godfrey Cuadros, Diego F medRxiv Article The HIV/AIDS epidemic remains critical in sub-Saharan Africa, with UNAIDS establishing “95-95-95” targets to optimize HIV care. Using the Zimbabwe Population-based HIV Impact Assessment (ZIMPHIA) geospatial data, this study aimed to identify patterns in these targets and determinants impacting the HIV care continuum in underserved Zimbabwean communities. Analysis techniques, including Gaussian kernel interpolation, optimized hotspot, and multivariate geospatial k-means clustering, were utilized to establish spatial patterns and cluster regional HIV care continuum needs. Further, we investigated healthcare availability, access, and social determinants and scrutinized the association between socio-demographic and behavioral covariates with HIV care outcomes. Disparities in progress toward the “95-95-95” targets were noted across different regions, with each target demonstrating unique geographic patterns, resulting in four distinct clusters with specific HIV care needs. Key factors associated with gaps in achieving targets included younger age, male sex, employment, and minority or no religious affiliation. Our study uncovers significant spatial heterogeneity in the HIV care continuum in Zimbabwe, with unique regional patterns in “95-95-95” targets. The spatial analysis of the UNAIDS targets presented here could prove instrumental in designing effective control strategies by identifying vulnerable communities that are falling short of these targets and require intensified efforts. Our result provides insights for designing region-specific interventions and enhancing community-level factors, emphasizing the need to address regional gaps and improve HIV care outcomes in vulnerable communities lagging behind. Cold Spring Harbor Laboratory 2023-07-28 /pmc/articles/PMC10402226/ /pubmed/37546877 http://dx.doi.org/10.1101/2023.07.26.23293207 Text en https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Chowdhury, MD Tuhin
Bershteyn, Anna
Milali, Masabho
Citron, Daniel
Nyimbili, Sulani
Musuka, Godfrey
Cuadros, Diego F
Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title_full Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title_fullStr Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title_full_unstemmed Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title_short Progress Towards UNAIDS’s 95-95-95 Targets in Zimbabwe: Sociodemographic Constraints and Geospatial Heterogeneity
title_sort progress towards unaids’s 95-95-95 targets in zimbabwe: sociodemographic constraints and geospatial heterogeneity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402226/
https://www.ncbi.nlm.nih.gov/pubmed/37546877
http://dx.doi.org/10.1101/2023.07.26.23293207
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