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The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsi...

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Autores principales: Huitsing, Kaylin, Tritsch, Tara, Arias, Francisco J. Carrera, Collado, Fanny, Aenlle, Kristina, Nathason, Lubov, Fletcher, Mary Ann, Klimas, Nancy G., Craddock, Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402253/
https://www.ncbi.nlm.nih.gov/pubmed/37546944
http://dx.doi.org/10.21203/rs.3.rs-3171709/v1
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author Huitsing, Kaylin
Tritsch, Tara
Arias, Francisco J. Carrera
Collado, Fanny
Aenlle, Kristina
Nathason, Lubov
Fletcher, Mary Ann
Klimas, Nancy G.
Craddock, Travis
author_facet Huitsing, Kaylin
Tritsch, Tara
Arias, Francisco J. Carrera
Collado, Fanny
Aenlle, Kristina
Nathason, Lubov
Fletcher, Mary Ann
Klimas, Nancy G.
Craddock, Travis
author_sort Huitsing, Kaylin
collection PubMed
description Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body’s defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a prolonged state of inflammation to eradicate any particular infection. Based on genetic analysis, and computational theory and modeling we hypothesize that mucin protein dysfunction may contribute to ME/CFS symptoms due to the inability to form adequate mucosal layers throughout the body, especially in the ocular and otolaryngological pathways leading to low grade chronic inflammation and the exacerbation of symptoms.
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spelling pubmed-104022532023-08-05 The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Huitsing, Kaylin Tritsch, Tara Arias, Francisco J. Carrera Collado, Fanny Aenlle, Kristina Nathason, Lubov Fletcher, Mary Ann Klimas, Nancy G. Craddock, Travis Res Sq Article Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body’s defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a prolonged state of inflammation to eradicate any particular infection. Based on genetic analysis, and computational theory and modeling we hypothesize that mucin protein dysfunction may contribute to ME/CFS symptoms due to the inability to form adequate mucosal layers throughout the body, especially in the ocular and otolaryngological pathways leading to low grade chronic inflammation and the exacerbation of symptoms. American Journal Experts 2023-07-24 /pmc/articles/PMC10402253/ /pubmed/37546944 http://dx.doi.org/10.21203/rs.3.rs-3171709/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Huitsing, Kaylin
Tritsch, Tara
Arias, Francisco J. Carrera
Collado, Fanny
Aenlle, Kristina
Nathason, Lubov
Fletcher, Mary Ann
Klimas, Nancy G.
Craddock, Travis
The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title_full The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title_fullStr The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title_full_unstemmed The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title_short The Potential Role of Ocular and Otolaryngological Mucus Proteins in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
title_sort potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/ chronic fatigue syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402253/
https://www.ncbi.nlm.nih.gov/pubmed/37546944
http://dx.doi.org/10.21203/rs.3.rs-3171709/v1
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