Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physi...

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Detalles Bibliográficos
Autores principales: Xie, Stanley C., Wang, Yinuo, Morton, Craig J., Metcalfe, Riley D., Dogovski, Con, Pasaje, Charisse Flerida A., Dunn, Elyse, Luth, Madeline R, Kumpornsin, Krittikorn, Istvan, Eva S, Park, Joon Sung, Fairhurst, Kate J., Ketprasit, Nutpakal, Yeo, Tomas, Yildirim, Okan, Bhebhe, Mathamsanqa N., Klug, Dana M., Rutledge, Peter J., Godoy, Luiz C., Dey, Sumanta, De Souza, Mariana Laureano, Siqueira-Neto, Jair L., Du, Yawei, Puhalovich, Tanya, Amini, Mona, Shami, Gerry, Loesbanluechai, Duangkamon, Nie, Shuai, Williamson, Nicholas, Jana, Gouranga P., Maity, Bikash C., Thomson, Patrick, Foley, Thomas, Tan, Derek S., Niles, Jacquin C, Han, Byung Woo, Goldberg, Daniel E, Burrows, Jeremy, Fidock, David A., Lee, Marcus C.S., Winzeler, Elizabeth A., Griffin, Michael D. W., Todd, Matthew H., Tilley, Leann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402266/
https://www.ncbi.nlm.nih.gov/pubmed/37546892
http://dx.doi.org/10.21203/rs.3.rs-3198291/v1

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