TIPS-20 A RANDOMIZED, CONTROLLED TRIAL OF BERUBICIN, A TOPOISOMERASE II POISON THAT APPEARS TO CROSS THE BLOOD-BRAIN BARRIER (BBB), AFTER FIRST-LINE THERAPY FOR GLIOBLASTOMA MULTIFORME (GBM): PRELIMINARY RESULTS

Berubicin is a doxorubicin (Dox) analog that appears to cross the BBB with significant central nervous system (CNS) uptake. Berubicin prolongs survival in orthotopic mouse intracranial models with greater infiltration of the tumor compared to normal tissue. A Phase 1 dose-escalation study showed mye...

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Detalles Bibliográficos
Autores principales: Silberman, Sandra, Hsu, Sigmund, Muzyczenko, Zena, Picker, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Trials in Progress
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402321/
http://dx.doi.org/10.1093/noajnl/vdad070.150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402321/
http://dx.doi.org/10.1093/noajnl/vdad070.150

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