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BSBM-09 IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES ß-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) AS A DRIVER OF NON-SMALL CELL LUNG CANCER BRAIN METASTASIS

Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumour and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Here...

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Detalles Bibliográficos
Autores principales:	Chafe, Shawn, Zhai, Kui, Aghaei, Nikoo, Miletic, Petar, Brown, Kevin, Mobilio, Daniel, Venugopal, Chitra, Kieliszek, Agata, Hynds, Robert, Lam, Fred, Moffat, Jason, Swanton, Charles, Bao, Shideng, Singh, Sheila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Basic Science of Brain Metastases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402323/ http://dx.doi.org/10.1093/noajnl/vdad070.005

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