SYST-03 PHASE 1B STUDY OF AVELUMAB AND WHOLE BRAIN RADIOTHERAPY (WBRT) IN PATIENTS WITH LEPTOMENINGEAL DISEASE (LMD) FROM EPITHELIAL CARCINOMAS: FINAL RESULTS AND MOLECULAR ANALYSES WITH SINGLE CELL RNA SEQUENCING

BACKGROUND: LMD has a dismal prognosis with median overall survival (mOS) of 3-4 months (mo). Preclinical studies showed PD-1 axis blocking therapy promotes antigen presentation within the CSF compartment, and increases BBB permeability and ingress of activated T cells into the meninges/CSF space. I...

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Detalles Bibliográficos
Autores principales: Pina, Yolanda, Chen, Ann, Arrington, John, Macaulay, Robert, Tran, Nam, Liu, James, Mokhtari, Sepideh, Li, Jiannong, Law, Vincent, Sahebjam, Solmaz, Ahmed, Kamran, Creelan, Ben, Gray, Jhanelle, Evernden, Brittany, Khushalani, Nikhil, Czerniecki, Brian, Smalley, Inna, Vogelbaum, Michael, Yu, Michael, Smalley, Keiran, Forsyth, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Final Category: Systemic Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402327/
http://dx.doi.org/10.1093/noajnl/vdad070.111

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