Cargando…

SYST-18 BELZUTIFAN TREATMENT FOR PATIENTS WITH VON HIPPEL-LINDAU DISEASE–ASSOCIATED CENTRAL NERVOUS SYSTEM HEMANGIOBLASTOMAS ENROLLED IN THE PHASE 2 LITESPARK-004 STUDY

Previous results of the ongoing single-arm, phase 2 LITESPARK-004 (NCT03401788) study showed clinically meaningful antitumor activity with the HIF-2α inhibitor belzutifan for von Hippel-Lindau (VHL) disease-associated renal cell carcinoma (RCC), CNS hemangioblastomas, and other neoplasms. Adults wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Narayan, Vivek, Iliopoulos, Othon, Iversen, Ane B, Maughan, Benjamin L, Beckermann, Kathryn E, Oudard, Stephane, Else, Tobias, Maranchie, Jodi K, Fu, Wei, Perini, Rodolfo F, Liu, Yanfang, Linehan, W Marston, Srinivasan, Ramaprasad, Jonasch, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Systemic Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402338/ http://dx.doi.org/10.1093/noajnl/vdad070.122

Ejemplares similares

First clinical experience with belzutifan in von Hippel–Lindau disease associated CNS hemangioblastoma
por: Dhawan, Andrew, et al.
Publicado: (2022)

Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL
por: Arevalo, Aileen, et al.
Publicado: (2022)

Resection of von Hippel Lindau Related Brainstem Hemangioblastoma
por: Maggio, Dominic, et al.
Publicado: (2019)

Obstructive azoospermia secondary to bilateral epididymal cystadenomas in a patient with von Hippel-Lindau
por: Gomella, Patrick T., et al.
Publicado: (2019)

Von Hippel-Lindau Syndrome: Diagnosis and Management of Hemangioblastoma and Pheochromocytoma
por: Vaganovs, P., et al.
Publicado: (2013)

Hemangioblast: origin of hemangioblastoma in von Hippel-Lindau (VHL) syndrome
por: Wang, Herui, et al.
Publicado: (2018)

Von Hippel-Lindau Disease: The Importance of Retinal Hemangioblastomas in Diagnosis
por: Şahin Atik, Sevinç, et al.
Publicado: (2017)

LITESPARK-024: A randomized phase 1/2 study of belzutifan with or without palbociclib for previously treated advanced renal cell carcinoma
por: McDermott, David F, et al.
Publicado: (2023)

Loss of Quiescence in von Hippel-Lindau Hemangioblastomas is Associated with Erythropoietin Signaling
por: Feldman, Michael J., et al.
Publicado: (2016)

Verteporfin photodynamic therapy of retinal capillary hemangioblastoma in von Hippel-Lindau disease
por: Bhattacharjee, Harsha, et al.
Publicado: (2010)

Midline basifrontal solid hemangioblastoma in non von hippel lindau syndrome patient
por: Sarkari, Avijit, et al.
Publicado: (2012)

Disseminated cerebellar hemangioblastoma in two patients without von Hippel–Lindau disease
por: Akimoto, Jiro, et al.
Publicado: (2014)

Disseminated Hemangioblastoma of the Central Nervous System without Von Hippel-Lindau Disease
por: Chung, Sun-Yoon, et al.
Publicado: (2014)

Retinal capillary hemangioblastoma associated with retinochoroidal coloboma in Von Hippel-Lindau disease
por: Mishra, Priyadarshini, et al.
Publicado: (2019)

von Hippel-Lindau Disease-Associated Hemangioblastomas Are Derived from Embryologic Multipotent Cells
por: Park, Deric M, et al.
Publicado: (2007)

Mutations in the von Hippel-Lindau Tumour Suppressor Gene in Central Nervous System Hemangioblastomas
por: Cybulski, Cezary, et al.
Publicado: (2004)

Spinal Cord Hemangioblastomas in von Hippel-Lindau Disease: Management of Asymptomatic and Symptomatic Tumors
por: Kim, Tae Yup, et al.
Publicado: (2012)

Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment
por: Klingler, Jan-Helge, et al.
Publicado: (2020)

Early microsurgical treatment for spinal hemangioblastomas improves outcome in patients with von Hippel–Lindau disease
por: Harati, Ali, et al.
Publicado: (2012)

Meningeal Supratentorial Hemangioblastoma in a Patient with Von Hippel-Lindau Disease Mimicking Angioblastic Menigioma
por: Kim, Hoon, et al.
Publicado: (2013)

A Case of von Hippel–Lindau Disease with Colorectal Adenocarcinoma, Renal Cell Carcinoma and Hemangioblastomas
por: Heo, Su Jin, et al.
Publicado: (2016)

Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients
por: Albiñana, Virginia, et al.
Publicado: (2015)

Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target
por: Sizdahkhani, Saman, et al.
Publicado: (2017)

Pathological and Clinical Features and Management of Central Nervous System Hemangioblastomas in von Hippel-Lindau Disease
por: Kanno, Hiroshi, et al.
Publicado: (2014)

Overexpression of EGFR and TGFα in von Hippel–Lindau-Related Central Nervous System Hemangioblastomas
por: Liu, Zhen, et al.
Publicado: (2020)

Outcome and genetic analysis of patients affected by retinal capillary hemangioblastoma in von Hippel Lindau syndrome
por: Murro, Vittoria, et al.
Publicado: (2021)

Long-Term Use of Intravitreal Bevacizumab (Avastin) for the Treatment of Von Hippel-Lindau Associated Retinal Hemangioblastomas
por: Hrisomalos, Frank N, et al.
Publicado: (2010)

Optical Coherence Tomography Angiography of Early Stage 1a Retinal Hemangioblastoma in Von-Hippel-Lindau
por: Goswami, Ananya, et al.
Publicado: (2021)

Retinal Glial Cells in Von Hippel–Lindau Disease: A Novel Approach in the Pathophysiology of Retinal Hemangioblastoma
por: Pilotto, Elisabetta, et al.
Publicado: (2021)

Sporadic and von Hippel–Lindau Related Hemangioblastomas of Brain and Spinal Cord: Multimodal Imaging for Intraoperative Strategy
por: Mazzapicchi, Elio, et al.
Publicado: (2022)

Retinal hemangioblastoma in a patient with Von Hippel-Lindau disease: A case report and literature review
por: Huang, Yikeng, et al.
Publicado: (2022)

Von-Hippel Lindau (VHL) syndrome with bilateral cerebellar hemangioblastomas and retinal angiomas: A rare presentation
por: Acharya, Abhijit, et al.
Publicado: (2023)

SYST-08 ROLE OF THE MICROBIOME IN BRAIN TUMORS
por: Omer, Mohammed
Publicado: (2023)

Systemic Therapy Development in Von Hippel–Lindau Disease: An Outsized Contribution from an Orphan Disease
por: Narayan, Vivek, et al.
Publicado: (2022)

Hemangioblastoma of the optic nerve producing bilateral optic tract edema in a patient with von Hippel–Lindau disease
por: Staub, Blake N., et al.
Publicado: (2014)

Microsurgical Treatment of Sporadic and von Hippel-Lindau Disease Associated Spinal Hemangioblastomas: A Single-Institution Experience
por: Das, Joe M., et al.
Publicado: (2017)

Sporadic Intradural Extramedullary Hemangioblastoma Not Associated with von Hippel-Lindau Syndrome: A Case Report and Literature Review
Publicado: (2021)

Pilot study of dovitinib in patients with von Hippel-Lindau disease
por: Pilié, Patrick, et al.
Publicado: (2018)

Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer
por: Cherkasova, Elena, et al.
Publicado: (2011)

Von Hippel-Lindau Disease
por: Hes, Frederik J, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_j5pkgrpfeocmqrfagkpggocpn5