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LMAP-21 PRELIMINARY CLINICAL DATA IN THE PHASE 1/2A DOSE ESCALATION TRIAL OF RHENIUM (186RE) OBISBEMEDA (186RNL) IN LEPTOMENINGEAL METASTASES (LM): THE RESPECT-LM TRIAL

OBJECTIVES: Leptomeningeal metastases (LM) are an increasing complication of metastatic cancer with limited treatment options and poor survival. 186RNL is BMEDA-chelated 186Re encapsulated in nanoliposomes. 186Re’s ~2 mm beta emission path length provides direct delivery of radiation therapy while s...

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Detalles Bibliográficos
Autores principales:	Youssef, Michael, Bao, Ande, Phillips, William, Hedrick, Marc, Moore, Melissa, LaFrance, Norman, Patel, Toral, Floyd, John, Brenner, Andrew, Michalek, Joel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Final Category: Local and Multimodality Approaches
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10402342/ http://dx.doi.org/10.1093/noajnl/vdad070.052

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